As advances in the molecular and genetic profiling of pediatric medulloblastoma evolve,
associations with prognosis and treatment are found (prognostic and predictive biomarkers) …

Wet age-related macular degeneration (wet AMD) is a primary contributor to visual
impairment and severe vision loss globally, but the prevailing treatments are often …

Malignant melanoma is the deadliest form of all skin cancers. Itraconazole, a commonly
used systemic antifungal drug, has been tested for its anti-tumor effects on basal cell …

Aberrant cholesterol homeostasis and biosynthesis has been observed in different tumour
types. This paper investigates the role of the post-squalenic enzyme of cholesterol …

Adrenomedullin (AM) is a 52 amino acid peptide that plays a regulatory role in the
vasculature. Receptors for AM comprise the class BG protein-coupled receptor, the …

Impaired 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2)-dependent cortisol
inactivation can lead to electrolyte dysbalance, hypertension and cardiometabolic disease …

Infantile hemangiomas can present a therapeutic challenge to clinicians, especially when
associated with severe pain and feeding difficulties. The standard therapeutic management …

Sorafenib is a multikinase inhibitor employed for managing hepatocellular carcinoma
(HCC). The emergence of sorafenib resistance presents an obstacle to its therapeutic …

Most anticancer drugs, particularly paclitaxel (PTX), are suffering the challenges of cancer
chemotherapy due to their poor water‐solubility, high toxicity under effective therapeutic …

Combinations of two different therapeutic modalities of VEGF inhibitors against
angiogenesis can cooperatively impede breast cancer tumor growth and enhance …