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Sex and gender differences in risk, pathophysiology and complications of type 2 diabetes mellitus
The steep rise of type 2 diabetes mellitus (T2DM) and associated complications go along
with mounting evidence of clinically important sex and gender differences. T2DM is more …
with mounting evidence of clinically important sex and gender differences. T2DM is more …
Epigenetic responses and the developmental origins of health and disease
Maternal and paternal factors influence offspring development and program its genome for
successful postnatal life. Based on the stressors during gestation, the pregnant female …
successful postnatal life. Based on the stressors during gestation, the pregnant female …
Epigenetic mechanisms of transmission of metabolic disease across generations
Both human and animal studies indicate that environmental exposures experienced during
early life can robustly influence risk for adult disease. Moreover, environmental exposures …
early life can robustly influence risk for adult disease. Moreover, environmental exposures …
Genetics and epigenetics: new insight on gestational diabetes mellitus
MG Dalfrà, S Burlina, GG Del Vescovo… - Frontiers in …, 2020 - frontiersin.org
Gestational diabetes mellitus (GDM) is the most common metabolic complication of
pregnancy, with a prevalence that has increased significantly in the last decade, coming to …
pregnancy, with a prevalence that has increased significantly in the last decade, coming to …
Growth hormone deficiency: health and longevity
The important role of GH in the control of mammalian longevity was first deduced from
extended longevity of mice with genetic GH deficiency (GHD) or GH resistance. Mice with …
extended longevity of mice with genetic GH deficiency (GHD) or GH resistance. Mice with …
Epigenetics and metabolism
The molecular signatures of epigenetic regulation and chromatin architectures are
fundamental to genetically determined biological processes. Covalent and post-translational …
fundamental to genetically determined biological processes. Covalent and post-translational …
The role of diet and exercise in the transgenerational epigenetic landscape of T2DM
Epigenetic changes are caused by biochemical regulators of gene expression that can be
transferred across generations or through cell division. Epigenetic modifications can arise …
transferred across generations or through cell division. Epigenetic modifications can arise …
Cohort profile: the Dutch famine birth cohort (DFBC)—a prospective birth cohort study in the Netherlands
Purpose The Dutch famine birth cohort study was set up to investigate the effects of acute
maternal undernutrition of the 1944–1945 Dutch famine during the specific stages of …
maternal undernutrition of the 1944–1945 Dutch famine during the specific stages of …
Association between type 2 diabetes and prenatal exposure to the Ukraine famine of 1932–33: a retrospective cohort study
Background The effect of fetal and early childhood living conditions on adult health has long
been debated, but empirical assessment in human beings remains a challenge. We used …
been debated, but empirical assessment in human beings remains a challenge. We used …
Low birthweight as a risk factor for non-communicable diseases in adults
ME Bianchi, JM Restrepo - Frontiers in medicine, 2022 - frontiersin.org
According to studies undertaken over the past 40 years, low birthweight (LBW) is not only a
significant predictor of perinatal death and morbidity, but also increases the risk of chronic …
significant predictor of perinatal death and morbidity, but also increases the risk of chronic …