Epitope map** of tetanus toxin by monoclonal antibodies: Implication for immunotherapy and vaccine design
Tetanus as a life-threatening disease is characterized by muscle spasm. The disease is
caused by the neurotoxin of Clostridium tetani. Active form of tetanus neurotoxin is …
caused by the neurotoxin of Clostridium tetani. Active form of tetanus neurotoxin is …
Structural basis of tetanus toxin neutralization by native human monoclonal antibodies
Y Wang, C Wu, J Yu, S Lin, T Liu, L Zan, N Li, P Hong… - Cell reports, 2021 - cell.com
Four potent native human monoclonal antibodies (mAbs) targeting distinct epitopes on
tetanus toxin (TeNT) are isolated with neutralization potency ranging from approximately 17 …
tetanus toxin (TeNT) are isolated with neutralization potency ranging from approximately 17 …
High-Throughput IgG Epitope Map** of Tetanus Neurotoxin: Implications for Immunotherapy and Vaccine Design
SG De-Simone, P Napoleão-Pêgo, GC Lechuga… - Toxins, 2023 - mdpi.com
Tetanus is an acute, fatal disease caused by exotoxins released from Clostridium tetani
during infections. A protective humoral immune response can be induced by vaccinations …
during infections. A protective humoral immune response can be induced by vaccinations …
Comparative in vitro and in vivo assessment of toxin neutralization by anti-tetanus toxin monoclonal antibodies
M Yousefi, R Khosravi-Eghbal… - Human vaccines & …, 2014 - Taylor & Francis
Tetanus is caused by the tetanus neurotoxin (TeNT), a 150 kDa single polypeptide molecule
which is cleaved into an active two-chain molecule composed of a 50 kDa N-terminal light …
which is cleaved into an active two-chain molecule composed of a 50 kDa N-terminal light …
A Dual Strategy—In Vitro and In Silico—To Evaluate Human Antitetanus mAbs Addressing Their Potential Protective Action on TeNT Endocytosis in Primary Rat …
CP Lima, GM Barreiros, ASA Oliveira… - International Journal of …, 2024 - mdpi.com
Tetanus disease, caused by C. tetani, starts with wounds or mucous layer contact. Prevented
by vaccination, the lack of booster shots throughout life requires prophylactic treatment in …
by vaccination, the lack of booster shots throughout life requires prophylactic treatment in …
[HTML][HTML] Tetanus vaccine-induced human neutralizing antibodies provide full protection against neurotoxin challenge in mice
G Zhang, R Yu, X Chi, Z Chen, M Hao, P Du… - International …, 2021 - Elsevier
Clostridium tetani causes life-threatening disease by producing tetanus neurotoxin (TeNT),
one of the most toxic protein substances. Toxicosis can be prevented and cured by …
one of the most toxic protein substances. Toxicosis can be prevented and cured by …
Evaluation of EBV transformation of human memory B-cells isolated by FACS and MACS techniques
Several studies have been performed to develop effective neutralizing monoclonal
antibodies. The Epstein–Barr virus (EBV) can efficiently immortalize B-cells to establish …
antibodies. The Epstein–Barr virus (EBV) can efficiently immortalize B-cells to establish …
Neutralization of tetanus toxin by a novel chimeric monoclonal antibody
Purpose Tetanus is a life-threatening disease characterized by muscle spasm caused by
neurotoxin of Clostridium tetani. Given the current passive immunotherapy of tetanus with …
neurotoxin of Clostridium tetani. Given the current passive immunotherapy of tetanus with …
The immunogenicity of the C fragment of tetanus neurotoxin in production of tetanus antitoxin
R Yu, C Ji, J Xu, D Wang, T Fang, Y **g… - BioMed Research …, 2018 - Wiley Online Library
The demand of tetanus antitoxin (TAT) as tetanus treatment in develo** and
underdeveloped countries is still great since it is relatively easy to achieve and affordable …
underdeveloped countries is still great since it is relatively easy to achieve and affordable …