RNA-Seq is a recently developed approach to transcriptome profiling that uses deep-
sequencing technologies. Studies using this method have already altered our view of the …

Claudins are tetraspan transmembrane proteins of tight junctions. They determine the
barrier properties of this type of cell–cell contact existing between the plasma membranes of …

Chemical genomics aims to comprehensively define, and ultimately predict, the effects of
small molecule compounds on biological systems. Chemical activity profiling approaches …

Alternative splicing is widely recognized for its roles in regulating genes and creating gene
diversity. However, despite many efforts, the repertoire of gene splicing variation is still …

We have mapped and quantified mouse transcriptomes by deeply sequencing them and
recording how frequently each gene is represented in the sequence sample (RNA-Seq) …

Abstract The University of California Santa Cruz Genome Browser Database (GBD) contains
sequence and annotation data for the genomes of about a dozen vertebrate species and …

Abstract The University of California, Santa Cruz Genome Browser (http://genome. ucsc.
edu) offers online access to a database of genomic sequence and annotation data for a …

The blood system is sustained by a pool of haematopoietic stem cells (HSCs) that are long-
lived due to their capacity for self-renewal. A consequence of longevity is exposure to stress …

Vertebrate glycoproteins and glycolipids are synthesized in complex biosynthetic pathways
localized predominantly within membrane compartments of the secretory pathway. The …

A major proportion of the mammalian transcriptome comprises long RNAs that have little or
no protein-coding capacity (ncRNAs). Only a handful of such transcripts have been …