Neurotransmitter systems in the etiology of major neurological disorders: Emerging insights and therapeutic implications
Neurotransmitters serve as chemical messengers playing a crucial role in information
processing throughout the nervous system, and are essential for healthy physiological and …
processing throughout the nervous system, and are essential for healthy physiological and …
Mechanisms underlying dorsolateral prefrontal cortex contributions to cognitive dysfunction in schizophrenia
Kraepelin, in his early descriptions of schizophrenia (SZ), characterized the illness as having
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …
Glutamatergic and GABAergic metabolite levels in schizophrenia-spectrum disorders: a meta-analysis of 1H-magnetic resonance spectroscopy studies
Abstract Background The glutamate (Glu) and gamma aminobutyric acid (GABA)
hypotheses of schizophrenia were proposed in the 1980s. However, current findings on …
hypotheses of schizophrenia were proposed in the 1980s. However, current findings on …
Prefrontal cortex and social cognition in mouse and man
Social cognition is a complex process that requires the integration of a wide variety of
behaviors, including salience, reward-seeking, motivation, knowledge of self and others …
behaviors, including salience, reward-seeking, motivation, knowledge of self and others …
Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders
R Gao, P Penzes - Current molecular medicine, 2015 - ingentaconnect.com
Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlap** behavioral phenotypes, which suggests …
complex genetic architectures but overlap** behavioral phenotypes, which suggests …
Alterations in cortical network oscillations and parvalbumin neurons in schizophrenia
Cognitive deficits are a core clinical feature of schizophrenia but respond poorly to available
medications. Thus, understanding the neural basis of these deficits is crucial for the …
medications. Thus, understanding the neural basis of these deficits is crucial for the …
Alterations in cortical interneurons and cognitive function in schizophrenia
Certain clinical features of schizophrenia, such as working memory disturbances, appear to
emerge from altered gamma oscillatory activity in the prefrontal cortex (PFC). Given the …
emerge from altered gamma oscillatory activity in the prefrontal cortex (PFC). Given the …
Interneuron dysfunction in psychiatric disorders
O Marín - Nature Reviews Neuroscience, 2012 - nature.com
Schizophrenia, autism and intellectual disabilities are best understood as spectrums of
diseases that have broad sets of causes. However, it is becoming evident that these …
diseases that have broad sets of causes. However, it is becoming evident that these …
The polygenic architecture of schizophrenia—rethinking pathogenesis and nosology
Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality.
Although the past two decades have seen limited improvement in the treatment of …
Although the past two decades have seen limited improvement in the treatment of …
Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia
Deficits in cognitive control, a core disturbance of schizophrenia, appear to emerge from
impaired prefrontal gamma oscillations. Cortical gamma oscillations require strong inhibitory …
impaired prefrontal gamma oscillations. Cortical gamma oscillations require strong inhibitory …