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Luteolin, a flavone ingredient: Anticancer mechanisms, combined medication strategy, pharmacokinetics, clinical trials, and pharmaceutical researches
Current pharmaceutical research is energetically excavating the pharmacotherapeutic role
of herb‐derived ingredients in multiple malignancies' targeting. Luteolin is one of the major …
of herb‐derived ingredients in multiple malignancies' targeting. Luteolin is one of the major …
Heme-thiolate monooxygenase cytochrome P450 1B1, an old dog with many new tricks
ABSTRACT Cytochrome P450 (CYP) 1B1 is a heme-thiolate monooxygenase traditionally
recognized for its xenobiotic functions and extrahepatic expressions. Recent studies have …
recognized for its xenobiotic functions and extrahepatic expressions. Recent studies have …
Urolithin A increases the natural killer activity of PBMCs in patients with prostate cancer
Background The natural killer (NK) activity of peripheral blood mononuclear cells (PBMCs)
is a crucial defense against the onset and spread of cancer. Studies have shown that …
is a crucial defense against the onset and spread of cancer. Studies have shown that …
[HTML][HTML] In Silico Exploration of AHR-HIF Pathway Interplay: Implications for Therapeutic Targeting in ccRCC
The oxygen-sensing pathway is a crucial regulatory circuit that defines cellular conditions
and is extensively exploited in cancer development. Pathogenic mutations in the von Hippel …
and is extensively exploited in cancer development. Pathogenic mutations in the von Hippel …
Clofazimine inhibits small-cell lung cancer progression by modulating the kynurenine/aryl hydrocarbon receptor axis
Small cell lung cancer (SCLC) is one of the highly metastatic malignancies that contributes
to∼ 15% of all lung cancers. Most SCLC patients (50–60%) develop osteolytic bone …
to∼ 15% of all lung cancers. Most SCLC patients (50–60%) develop osteolytic bone …
A pyrazolopyridine as a novel AhR signaling activator with anti-breast cancer properties in vitro and in vivo
Breast cancer is one of the main causes of malignancy-related deaths globally and has a
significant impact on women's quality of life. Despite significant therapeutic advances, there …
significant impact on women's quality of life. Despite significant therapeutic advances, there …
[HTML][HTML] Discovery of a novel AhR–CYP1A1 axis activator for mitigating inflammatory diseases using an in situ functional imaging assay
The aryl hydrocarbon receptor (AhR) plays a crucial role in regulating many physiological
processes. Activating the AhR–CYP1A1 axis has emerged as a novel therapeutic strategy …
processes. Activating the AhR–CYP1A1 axis has emerged as a novel therapeutic strategy …
Unveiling the Immune effects of AHR in tumors: a decade of insights from bibliometric analysis (2010–2023)
A **e, T Wang, W Shi, F He, X Sun, P Li - Discover Oncology, 2024 - Springer
Abstract Background The Aryl Hydrocarbon Receptor (AHR) is a transcription factor that
regulates several biological processes. Its potential in anti-tumor immunotherapy is …
regulates several biological processes. Its potential in anti-tumor immunotherapy is …
Carbidopa and ZnCarbidopa Induce Reductive Stress in MDA‐MB‐231 Cells
AB Actis Dato, LG Naso, VR Martínez, EG Ferrer… - ChemPlusChem - Wiley Online Library
The redox imbalance, caused by depletion or generation of reactive oxygen species (ROS),
is a key mechanism by which metal complexes exert anticancer effects. Carbidopa has …
is a key mechanism by which metal complexes exert anticancer effects. Carbidopa has …