Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

C Qin, S Yang, YH Chu, H Zhang, XW Pang… - Signal transduction and …, 2022‏ - nature.com
Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces
severe neural injuries, and is one of the leading causes of death and disability worldwide …

An update of Nrf2 activators and inhibitors in cancer prevention/promotion

F Pouremamali, A Pouremamali, M Dadashpour… - Cell Communication and …, 2022‏ - Springer
Abstract NF-E2-related factor 2 (Nrf2) protein is a basic-region leucine zipper transcription
factor that defends against endogenous or exogenous stressors. By inducing several …

Chemical characterization of honeysuckle polyphenols and their alleviating function on ultraviolet B-damaged HaCaT cells by modulating the Nrf2/NF-κB signaling …

SL Zheng, YM Wang, CF Chi, B Wang - Antioxidants, 2024‏ - mdpi.com
Scientific evidence attests that the epidermis receives excessive ultraviolet B (UVB)
radiation, triggering the generation of substantial quantities of reactive oxygen species …

[HTML][HTML] NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: molecular mechanisms and possible therapeutic approaches

F Sivandzade, S Prasad, A Bhalerao, L Cucullo - Redox biology, 2019‏ - Elsevier
Electrophiles and reactive oxygen species (ROS) play a major role in modulating cellular
defense mechanisms as well as physiological functions, and intracellular signaling …

Antioxidant metabolism pathways in vitamins, polyphenols, and selenium: parallels and divergences

CMC Andrés, JM Pérez de la Lastra, CA Juan… - International Journal of …, 2024‏ - mdpi.com
Free radicals (FRs) are unstable molecules that cause reactive stress (RS), an imbalance
between reactive oxygen and nitrogen species in the body and its ability to neutralize them …

The influence of gut dysbiosis in the pathogenesis and management of ischemic stroke

SB Chidambaram, AG Rathipriya, AM Mahalakshmi… - Cells, 2022‏ - mdpi.com
Recent research on the gut microbiome has revealed the influence of gut microbiota (GM)
on ischemic stroke pathogenesis and treatment outcomes. Alterations in the diversity …

Plasma medicine: A field of applied redox biology

T Von Woedtke, A Schmidt, S Bekeschus, K Wende… - In vivo, 2019‏ - iv.iiarjournals.org
Plasma medicine comprises the application of physical plasma directly on or in the human
body for therapeutic purposes. Three most important basic plasma effects are relevant for …

[HTML][HTML] Nrf2 signaling pathway: current status and potential therapeutic targetable role in human cancers

L Lin, Q Wu, F Lu, J Lei, Y Zhou, Y Liu, N Zhu… - Frontiers in …, 2023‏ - frontiersin.org
Cancer is a borderless global health challenge that continues to threaten human health.
Studies have found that oxidative stress (OS) is often associated with the etiology of many …

Smart liposomal nanocarrier enhanced the treatment of ischemic stroke through neutrophil extracellular traps and cyclic guanosine monophosphate-adenosine …

S Sun, W Lv, S Li, Q Zhang, W He, Z Min, C Teng… - ACS …, 2023‏ - ACS Publications
Brain inflammation is regarded as one of the leading causes that aggravates secondary
brain injury and hinders the prognosis of ischemic stroke. After ischemic stroke, high …

The role of oxidative stress in the pathogenesis of vitiligo: a culprit for melanocyte death

Y Xuan, Y Yang, L **ang… - Oxidative medicine and …, 2022‏ - Wiley Online Library
Vitiligo is a common chronic acquired pigmentation disorder characterized by loss of
pigmentation. Among various hypotheses proposed for the pathogenesis of vitiligo, oxidative …