Extensive research on humans suggests that exercise could have benefits for overall health
and cognitive function, particularly in later life. Recent studies using animal models have …

Brain-derived neurotrophic factor (BDNF) promotes neuroprotection and neuroregeneration.
In animal models of Parkinson's disease (PD), BDNF enhances the survival of dopaminergic …

The concept of a “polypill” is receiving growing attention to prevent cardiovascular disease.
Yet similar if not overall higher benefits are achievable with regular exercise, a drug-free …

We have investigated a potential mechanism by which a diet, similar in composition to the
typical diet of most industrialized western societies rich in saturated fat and refined sugar …

Aims/hypothesis Brain-derived neurotrophic factor (BDNF) is produced in skeletal muscle,
but its functional significance is unknown. We aimed to determine the signalling processes …

We have investigated potential mechanisms by which exercise can promote changes in
neuronal plasticity via modulation of neurotrophins. Rodents were exposed to voluntary …

There has long been discussion regarding the positive effects of physical exercise on brain
activity. However, physical exercise has only recently begun to receive the attention of the …

Skeletal muscle is an essential regulator of energy homeostasis and a potent coordinator of
exercise-induced adaptations in other organs including the liver, fat or the brain. Skeletal …

Previous studies have suggested beneficial effects of physical activity on cognition. Here, we
asked in an interventional approach if physical activity performed at different intensity levels …

▪ Abstract Motor function is severely disrupted following spinal cord injury (SCI). The spinal
circuitry, however, exhibits a great degree of automaticity and plasticity after an injury …