There is substantial variation between individuals in the immune response to vaccination. In
this review, we provide an overview of the plethora of studies that have investigated factors …

Neonates have an immature immune system, which cannot adequately protect against
infectious diseases. Early in life, immune protection is accomplished by maternal antibodies …

Oral vaccines are less immunogenic when given to infants in low-income compared with
high-income countries, limiting their potential public health impact. Here, we review factors …

Rotaviruses are a major cause of acute gastroenteritis in infants and young children
worldwide and in many other mammalian and avian host species. Since 2006, two live …

Rotavirus is the leading cause of diarrheal death among children< 5 years old worldwide,
estimated to have caused~ 215,000 deaths in 2013. Prior to rotavirus vaccine …

Infants are born with immature immune systems, making it difficult for them to effectively
respond to the infectious pathogens encountered shortly after birth. Maternal antibody is …

Introduction: Numerous studies have shown that the oral rotavirus vaccines are less effective
in infants born in low income countries compared to those born in developed countries …

In the decade since oral rotavirus vaccines (ORV) were recommended by the World Health
Organization for universal inclusion in all national immunization programs, significant yet …