A n D GUID eLIneS affordability may often dictate which medications may be prescribed.
Patients who have exhausted prescription drug coverage or who are uninsured may require …

Membrane transporters are now recognized as important determinants of the
transmembrane passage of drugs. Organic anion transporting polypeptides (OATP) form a …

The importance of membrane transporters for drug pharmacokinetics has been increasingly
recognized during the last decade. Organic anion transporting polypeptide 1B1 (OATP1B1) …

Lipid‐lowering drugs, especially 3‐hydroxy‐3‐methylglutaryl–coenzyme A inhibitors
(statins), are widely used in the treatment and prevention of atherosclerotic disease. The …

Abstract During the last 10-15 years, cytochrome P450 (CYP) 2C8 has emerged as an
important drug-metabolizing enzyme. CYP2C8 is highly expressed in human liver and is …

Variability of drug metabolism, especially that of the most important phase I enzymes or
cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of …

Statin-related myopathy is a clinically important cause of statin intolerance and
discontinuation. The spectrum of statin-related myopathy ranges from common but clinically …

Introduction: Statin-induced myopathy is an important cause of statin intolerance and the
most common cause of statin discontinuation. Observational studies estimate that 10–15 …

Background & Aims The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
inhibitors, or statins, target liver HMG-CoA and are of proven benefit in the prevention of …

Peroxisome proliferator–activated receptors (PPARs) play key roles in the regulation of
energy homeostasis and inflammation, and agonists of PPARα and-γ are currently used …