Precision drug delivery to the central nervous system using engineered nanoparticles

J Gao, Z **a, S Gunasekar, C Jiang, JM Karp… - Nature Reviews …, 2024‏ - nature.com
Abstract Development of novel therapies for central nervous system (CNS) disorders has
experienced a high failure rate in clinical trials owing to unsatisfactory efficacy and adverse …

[HTML][HTML] Cellular uptake and retention of nanoparticles: Insights on particle properties and interaction with cellular components

R Augustine, A Hasan, R Primavera, RJ Wilson… - Materials Today …, 2020‏ - Elsevier
The utilization of nanomaterials in the biological and medical field is quickly progressing,
particularly in areas where traditional diagnostics and treatment approaches have limited …

[HTML][HTML] Progress in regulating inflammatory biomaterials for intervertebral disc regeneration

H **ang, W Zhao, K Jiang, J He, L Chen, W Cui, Y Li - Bioactive Materials, 2024‏ - Elsevier
Intervertebral disc degeneration (IVDD) is rising worldwide and leading to significant health
issues and financial strain for patients. Traditional treatments for IVDD can alleviate pain but …

Biologically synthesized green gold nanoparticles from Siberian ginseng induce growth-inhibitory effect on melanoma cells (B16)

F Wu, J Zhu, G Li, J Wang… - Artificial cells …, 2019‏ - Taylor & Francis
Siberian ginseng, perennial herb belongs to Araliaceae family used in traditional medicines
to treat hypertension, thrombus, inflammation and cancer. In the present study, we …

The charming world of the extracellular matrix: a dynamic and protective network of the intestinal wall

S Pompili, G Latella, E Gaudio, R Sferra… - Frontiers in …, 2021‏ - frontiersin.org
The intestinal extracellular matrix (ECM) represents a complex network of proteins that not
only forms a support structure for resident cells but also interacts closely with them by …

The protein corona hampers the transcytosis of transferrin-modified nanoparticles through blood–brain barrier and attenuates their targeting ability to brain tumor

W **ao, Y Wang, H Zhang, Y Liu, R **e, X He, Y Zhou… - Biomaterials, 2021‏ - Elsevier
The modification of targeting ligands on nanoparticles (NPs) is anticipated to enhance the
delivery of therapeutics to diseased tissues. However, once exposed to the blood stream …

Application of nano-delivery systems in lymph nodes for tumor immunotherapy

Y **a, S Fu, Q Ma, Y Liu, N Zhang - Nano-micro letters, 2023‏ - Springer
Immunotherapy has become a promising research “hotspot” in cancer treatment.“Soldier”
immune cells are not uniform throughout the body; they accumulate mostly in the immune …

Targeting endothelial permeability in the EPR effect

B Lahooti, RG Akwii, FT Zahra, MS Sajib… - Journal of Controlled …, 2023‏ - Elsevier
The characteristics of the primary tumor blood vessels and the tumor microenvironment drive
the enhanced permeability and retention (EPR) effect, which confers an advantage towards …

Green synthesis of silver nanoparticles toward bio and medical applications: review study

SM Mousavi, SA Hashemi, Y Ghasemi… - Artificial cells …, 2018‏ - Taylor & Francis
Abstract Development of biologically inspired green synthesis of silver nanoparticles has
attracted considerable worldwide attention in matter of medical science and disease …

Musculoskeletal Organs‐on‐Chips: An Emerging Platform for Studying the Nanotechnology–Biology Interface

Y Wang, P Yung, G Lu, Y Liu, C Ding, C Mao… - Advanced …, 2025‏ - Wiley Online Library
Nanotechnology‐based approaches are promising for the treatment of musculoskeletal
(MSK) disorders, which present significant clinical burdens and challenges, but their clinical …