Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐and aging‐related diseases

AG Panossian, T Efferth, AN Shikov… - Medicinal research …, 2021 - Wiley Online Library
Adaptogens comprise a category of herbal medicinal and nutritional products promoting
adaptability, resilience, and survival of living organisms in stress. The aim of this review was …

The role of adaptogens in prophylaxis and treatment of viral respiratory infections

A Panossian, T Brendler - Pharmaceuticals, 2020 - mdpi.com
The aim of our review is to demonstrate the potential of herbal preparations, specifically
adaptogens for prevention and treatment of respiratory infections, as well as convalescence …

A literature review of the studies concerning selected plant-derived adaptogens and their general function in body with a focus on animal studies

N Esmaealzadeh, A Iranpanah, J Sarris, R Rahimi - Phytomedicine, 2022 - Elsevier
Background Adaptogens are generally referred to the substances, mostly found in plants,
which non-specifically increase resilience and chances of survival by activation of signaling …

Non‐psychotropic Cannabis sativa L. phytocomplex modulates microglial inflammatory response through CB2 receptors‐, endocannabinoids‐, and NF‐κB‐mediated …

V Borgonetti, C Benatti, P Governa… - Phytotherapy …, 2022 - Wiley Online Library
Cannabis sativa L. is increasingly emerging for its protective role in modulating
neuroinflammation, a complex process orchestrated among others by microglia, the resident …

[HTML][HTML] Salidroside inhibits NLRP3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the TLR4/NF-κB …

J Liu, W Ma, CH Zang, GD Wang… - Annals of …, 2021 - ncbi.nlm.nih.gov
Background The NOD-like receptor family pyrin domain-containing 3 (NLRP3)
inflammasome is an important mediator of neuroinflammatory responses that regulates …

Effects of Rhodiola rosea supplementation on exercise and sport: a systematic review

Y Lu, B Deng, L Xu, H Liu, Y Song, F Lin - Frontiers in nutrition, 2022 - frontiersin.org
Rhodiola rosea (Golden Root Extract; RR) is an herbaceous perennial, which is native to
high altitude areas, such as East Asia, Central Asia, Siberia, and North America. It has been …

Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review

D Wróbel-Biedrawa, I Podolak - Molecules, 2024 - mdpi.com
Introduction: Adaptogens are a group of plants that exhibit complex, nonspecific effects on
the human body, increasing its ability to adapt, develop resilience, and survive in stress …

Microglia senescence is related to neuropathic pain–associated comorbidities in the spared nerve injury model

V Borgonetti, N Galeotti - Pain, 2023 - journals.lww.com
The increased presence of senescent cells in different neurological diseases suggests the
contribution of senescence in the pathophysiology of neurodegenerative disorders …

Novel Combination of Choline with Withania somnifera (L.) Dunal, and Bacopa monnieri (L.) Wetts Reduced Oxidative Stress in Microglia Cells, Promoting …

V Borgonetti, N Galeotti - International journal of molecular sciences, 2023 - mdpi.com
Memory deficit is one of the major negative outcomes of chronic stress. Cholinergic system
modulates memory not only through the neuronal cells, but also via interactions with non …

Rosavin: Research Advances in Extraction and Synthesis, Pharmacological Activities and Therapeutic Effects on Diseases of the Characteristic Active Ingredients of …

S Wang, Y Feng, L Zheng, P He, J Tan, J Cai, M Wu… - Molecules, 2023 - mdpi.com
Rhodiola rosea L.(RRL) is a popular plant in traditional medicine, and Rosavin, a
characteristic ingredient of RRL, is considered one of the most important active ingredients …