Epstein–Barr virus (EBV) is a ubiquitous virus that infects nearly all people worldwide
without serious sequela. However, for patients who have genetic diseases which predispose …

Haemophagocytic lymphohistiocytosis (HLH) comprises a heterogeneous spectrum of
hyperinflammatory conditions that are inherited (primary HLH) or acquired in a context of …

Isolated neuroinflammatory disease has been described in case reports of familial
hemophagocytic lymphohistiocytosis (FHL), but the clinical spectrum of disease …

Objective To highlight a novel, treatable syndrome, we report 4 patients with CNS-isolated
inflammation associated with familial hemophagocytic lymphohistiocytosis (FHL) gene …

This article explores the distribution and mutation spectrum of potential disease-causing
genetic variants in hemophagocytic lymphohistiocytosis (HLH)–associated genes observed …

Haemophagocytic lymphohistiocytosis (HLH) is a possibly life-threatening syndrome of
immune dysregulation and can be divided into primary (hereditary) and secondary forms …

PRF1 (perforin 1) is a key cytotoxic molecule that plays a crucial role in the killing function of
natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). Recent studies have focused on …

Background The contribution of genetic factors to the severity of adult hemophagocytic
lymphohistiocytosis (HLHa) remains unclear. Objective We sought to assess a potential link …

Introduction Inborn errors of immunity (IEI) are characterized by a dysfunction of the immune
system leading to increased susceptibility to infections, impaired immune regulation and …

Background Immune checkpoint inhibitor therapy is a modern breakthrough in medical
oncology, but it can precipitate inflammatory and autoimmune adverse effects. Among the …