Rethinking amide bond synthesis

VR Pattabiraman, JW Bode - Nature, 2011 - nature.com
One of the most important reactions in organic chemistry—amide bond formation—is often
overlooked as a contemporary challenge because of the widespread occurrence of amides …

Nonclassical routes for amide bond formation

RM De Figueiredo, JS Suppo, JM Campagne - Chemical reviews, 2016 - ACS Publications
The present review offers an overview of nonclassical (eg, with no pre-or in situ activation of
a carboxylic acid partner) approaches for the construction of amide bonds. The review aims …

Large-scale applications of amide coupling reagents for the synthesis of pharmaceuticals

JR Dunetz, J Magano… - … Process Research & …, 2016 - ACS Publications
Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals |
Organic Process Research & Development ACS ACS Publications C&EN CAS Find my …

Large-scale amidations in process chemistry: practical considerations for reagent selection and reaction execution

J Magano - Organic Process Research & Development, 2022 - ACS Publications
This review describes the practical aspects involved in the implementation of large-scale
amidations in process chemistry. Coupling reagent, base, additive, and solvent selections …

Catalytic amide formation from non-activated carboxylic acids and amines

H Lundberg, F Tinnis, N Selander… - Chemical Society …, 2014 - pubs.rsc.org
The amide functionality is found in a wide variety of biological and synthetic structures such
as proteins, polymers, pesticides and pharmaceuticals. Due to the fact that synthetic amides …

Elucidating the Role of Antisolvents on the Surface Chemistry and Optoelectronic Properties of CsPbBrxI3-x Perovskite Nanocrystals

J Ye, Z Li, DJ Kubicki, Y Zhang, L Dai… - Journal of the …, 2022 - ACS Publications
Colloidal lead-halide perovskite nanocrystals (LHP NCs) have emerged over the past
decade as leading candidates for efficient next-generation optoelectronic devices, but their …

Boronic acid catalysis

DG Hall - Chemical Society Reviews, 2019 - pubs.rsc.org
Although boronic acids are recognized primarily for their utility as reagents in transition
metal-catalyzed transformations, other applications are emerging, including their use as …

Base-Catalyzed Aryl-B(OH)2 Protodeboronation Revisited: From Concerted Proton Transfer to Liberation of a Transient Aryl Anion

PA Cox, M Reid, AG Leach, AD Campbell… - Journal of the …, 2017 - ACS Publications
Pioneering studies by Kuivila, published more than 50 years ago, suggested ipso
protonation of the boronate as the mechanism for base-catalyzed protodeboronation of …

Palladium-catalyzed aerobic dehydrogenation of substituted cyclohexanones to phenols

Y Izawa, D Pun, SS Stahl - Science, 2011 - science.org
Aromatic molecules are key constituents of many pharmaceuticals, electronic materials, and
commodity plastics. The utility of these molecules directly reflects the identity and pattern of …

Cross Coupling of Acyl and Aminyl Radicals: Direct Synthesis of Amides Catalyzed by Bu4NI with TBHP as an Oxidant

Z Liu, J Zhang, S Chen, E Shi, Y Xu, X Wan - … Chemie International Edition, 2012 - infona.pl
A radical solution: A Bu 4 NI/tert‐butyl hydroperoxide (TBHP) catalyzed synthesis of amides
through a cross‐coupling reaction between acyl and aminyl radicals is described. This …