Cancer immunotherapy with γδ T cells: many paths ahead of us

D Kabelitz, R Serrano, L Kouakanou, C Peters… - Cellular & molecular …, 2020 - nature.com
Abstract γδ T cells play uniquely important roles in stress surveillance and immunity for
infections and carcinogenesis. Human γδ T cells recognize and kill transformed cells …

[HTML][HTML] Current understanding of plant-derived exosome-like nanoparticles in regulating the inflammatory response and immune system microenvironment

Q Yi, Z Xu, A Thakur, K Zhang, Q Liang, Y Liu… - Pharmacological …, 2023 - Elsevier
Natural compounds are widely used to prevent and treat various diseases due to their
antioxidant and anti-inflammatory effects. As a kind of promising natural compound, plant …

GSCA: an integrated platform for gene set cancer analysis at genomic, pharmacogenomic and immunogenomic levels

CJ Liu, FF Hu, GY **e, YR Miao, XW Li… - Briefings in …, 2023 - academic.oup.com
Cancer initiation and progression are likely caused by the dysregulation of biological
pathways. Gene set analysis (GSA) could improve the signal-to-noise ratio and identify …

First-line durvalumab and tremelimumab with chemotherapy in RAS-mutated metastatic colorectal cancer: a phase 1b/2 trial

M Thibaudin, JD Fumet, B Chibaudel, J Bennouna… - Nature Medicine, 2023 - nature.com
Although patients with microsatellite instable metastatic colorectal cancer (CRC) benefit from
immune checkpoint blockade, chemotherapy with targeted therapies remains the only …

T-cell exhaustion signatures characterize the immune landscape and predict HCC prognosis via integrating single-cell RNA-seq and bulk RNA-sequencing

H Chi, S Zhao, J Yang, X Gao, G Peng… - Frontiers in …, 2023 - frontiersin.org
Background Hepatocellular carcinoma (HCC), the third most prevalent cause of cancer-
related death, is a frequent primary liver cancer with a high rate of morbidity and mortality. T …

Crosstalk between 5-methylcytosine and N6-methyladenosine machinery defines disease progression, therapeutic response and pharmacogenomic landscape in …

Y Tian, H **ao, Y Yang, P Zhang, J Yuan, W Zhang… - Molecular cancer, 2023 - Springer
Background Accumulated evidence highlights the significance of the crosstalk between
epigenetic and epitranscriptomic mechanisms, notably 5-methylcytosine (5mC) and N6 …

Expression profile of immune checkpoint genes and their roles in predicting immunotherapy response

FF Hu, CJ Liu, LL Liu, Q Zhang… - Briefings in …, 2021 - academic.oup.com
Immune checkpoint genes (ICGs) play critical roles in circumventing self-reactivity and
represent a novel target to develop treatments for cancers. However, a comprehensive …

CD8 T cell score as a prognostic biomarker for triple negative breast cancer

M Oshi, M Asaoka, Y Tokumaru, L Yan… - International journal of …, 2020 - mdpi.com
CD8 T cell is an essential component of tumor-infiltrating lymphocytes (TIL) and tumor
immune microenvironment (TIME). Using the xCell CD8 T cell score of whole tumor gene …

Interaction between chronic endometritis caused endometrial microbiota disorder and endometrial immune environment change in recurrent implantation failure

P Chen, P Chen, Y Guo, C Fang, T Li - Frontiers in Immunology, 2021 - frontiersin.org
Objective To investigate the Interaction between chronic endometritis (CE) caused
endometrial microbiota disorder and endometrial immune environment change in recurrent …

Pan-cancer analysis shows that ALKBH5 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types including gliomas

C Wei, B Wang, D Peng, X Zhang, Z Li, L Luo… - Frontiers in …, 2022 - frontiersin.org
Background AlkB homolog 5 (ALKBH5) is a N6-methyladenosine (m6A) demethylase
associated with the development, growth, and progression of multiple cancer types …