Psoriasis vulgaris is a common, chronic inflammatory skin disease with a complex etiology
involving genetic risk factors and environmental triggers. Here we describe the many known …

The skin barrier is broadly composed of two elements—a physical barrier mostly localised in
the epidermis, and an immune barrier localised in both the dermis and epidermis. These two …

Psoriasis is a common, chronic papulosquamous skin disease occurring worldwide,
presenting at any age, and leading to a substantial burden for individuals and society. It is …

Psoriasis is a chronic inflammatory skin disease, the immunologic model of which has been
profoundly revised following recent advances in the understanding of its pathophysiology. In …

Psoriasis is a complex disease of skin with a prevalence of about 2%. We conducted the
largest meta-analysis of genome-wide association studies (GWAS) for psoriasis to date …

Perturbations in the transcriptional programs specifying epidermal differentiation cause
diverse skin pathologies ranging from impaired barrier function to inflammatory skin disease …

To gain further insight into the genetic architecture of psoriasis, we conducted a meta-
analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets …

The ability of mammals to mount adaptive immune responses culminating with the
establishment of immunological memory is predicated on the ability of the mature T cell …

Psoriasis is a chronic, immune‐mediated disease affecting more than 100 million people
worldwide and up to 2.2% of the UK population. The aetiology of psoriasis is thought to …

Individuals with Behçet's disease suffer from episodic inflammation often affecting the
orogenital mucosa, skin and eyes. To discover new susceptibility loci for Behçet's disease …