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Cannabinoids and cannabinoid receptors: The story so far
Like most modern molecular biology and natural product chemistry, understanding
cannabinoid pharmacology centers around molecular interactions, in this case, between the …
cannabinoid pharmacology centers around molecular interactions, in this case, between the …
Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown
PH Reggio - Current medicinal chemistry, 2010 - ingentaconnect.com
The cannabinoid CB1 and CB2 receptors are Class AG protein-coupled receptors (GPCRs).
While many Class A GPCRs have endogenous ligands that are hydrophilic cations (eg, the …
While many Class A GPCRs have endogenous ligands that are hydrophilic cations (eg, the …
A genetically encoded fluorescent sensor for rapid and specific in vivo detection of norepinephrine
Norepinephrine (NE) is a key biogenic monoamine neurotransmitter involved in a wide
range of physiological processes. However, its precise dynamics and regulation remain …
range of physiological processes. However, its precise dynamics and regulation remain …
Monitoring norepinephrine release in vivo using next-generation GRABNE sensors
Norepinephrine (NE) is an essential biogenic monoamine neurotransmitter. The first-
generation NE sensor makes in vivo, real-time, cell-type-specific and region-specific NE …
generation NE sensor makes in vivo, real-time, cell-type-specific and region-specific NE …
Smallest near-infrared fluorescent protein evolved from cyanobacteriochrome as versatile tag for spectral multiplexing
From a single domain of cyanobacteriochrome (CBCR) we developed a near-infrared (NIR)
fluorescent protein (FP), termed miRFP670nano, with excitation at 645 nm and emission at …
fluorescent protein (FP), termed miRFP670nano, with excitation at 645 nm and emission at …
A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor
Recent isothiocyanate covalent labeling studies have suggested that a classical
cannabinoid,(−)-7′-isothiocyanato-11-hydroxy-1′, 1′ dimethylheptyl …
cannabinoid,(−)-7′-isothiocyanato-11-hydroxy-1′, 1′ dimethylheptyl …
Lighting up the brain: genetically encoded fluorescent sensors for imaging neurotransmitters and neuromodulators
Highlights•Genetically-encoded fluorescent sensors are essential for studying
neurotransmission.•Today's sensors are limited in certain aspects, especially for in vivo …
neurotransmission.•Today's sensors are limited in certain aspects, especially for in vivo …
[HTML][HTML] Fluorescent approaches for understanding interactions of ligands with G protein coupled receptors
G protein coupled receptors are responsible for a wide variety of signaling responses in
diverse cell types. Despite major advances in the determination of structures of this class of …
diverse cell types. Despite major advances in the determination of structures of this class of …
Chemical probes shed light on protein function
Site-specific protein labeling with synthetic dyes is an emerging technique for live cell
imaging. A protein or peptide tag fused to the protein of interest provides the means for …
imaging. A protein or peptide tag fused to the protein of interest provides the means for …
Surveying polypeptide and protein domain conformation and association with FlAsH and ReAsH
Recombinant polypeptides and protein domains containing two cysteine pairs located distal
in primary sequence but proximal in the native folded or assembled state are labeled …
in primary sequence but proximal in the native folded or assembled state are labeled …