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Metabolic syndrome, aging and involvement of oxidative stress
The prevalence of the metabolic syndrome, a cluster of cardiovascular risk factors
associated with obesity and insulin resistance, is dramatically increasing in Western and …
associated with obesity and insulin resistance, is dramatically increasing in Western and …
A comprehensive overview of the complex role of oxidative stress in aging, the contributing environmental stressors and emerging antioxidant therapeutic …
Introduction Aging is a normal, inevitable, irreversible, and progressive process which is
driven by internal and external factors. Oxidative stress, that is the imbalance between …
driven by internal and external factors. Oxidative stress, that is the imbalance between …
HDL and cholesterol handling in the brain
Cholesterol is an essential component of both the peripheral nervous system and central
nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes …
nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes …
Intracellular cholesterol trafficking and impact in neurodegeneration
F Arenas, C Garcia-Ruiz… - Frontiers in Molecular …, 2017 - frontiersin.org
Cholesterol is a critical component of membrane bilayers where it plays key structural and
functional roles by regulating the activity of diverse signaling platforms and pathways …
functional roles by regulating the activity of diverse signaling platforms and pathways …
On the central role of mitochondria dysfunction and oxidative stress in Alzheimer's disease
TO Tobore - Neurological Sciences, 2019 - Springer
Background Alzheimer's disease (AD) is the commonest cause of dementia, with
approximately 5 million new cases occurring annually. Despite decades of research, its …
approximately 5 million new cases occurring annually. Despite decades of research, its …
Role of the blood–brain barrier in the nutrition of the central nervous system
The blood–brain barrier (BBB) is a dynamic and complex interface between the blood and
the central nervous system regulating brain homeostasis. Major functions of the BBB include …
the central nervous system regulating brain homeostasis. Major functions of the BBB include …
The metabolic syndrome, oxidative stress, environment, and cardiovascular disease: the great exploration
The metabolic syndrome affects 30% of the US population with increasing prevalence. In
this paper, we explore the relationship between the metabolic syndrome and the incidence …
this paper, we explore the relationship between the metabolic syndrome and the incidence …
Imbalanced cholesterol metabolism in Alzheimer's disease
Z Xue-Shan, W Qi, R Zhong, P Li-hong, T Zhi-han… - Clinica Chimica …, 2016 - Elsevier
Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disease that is
mainly caused by β-amyloid accumulation. A large number of studies have shown that …
mainly caused by β-amyloid accumulation. A large number of studies have shown that …
[HTML][HTML] Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment
An intact blood-brain barrier (BBB) limits entry of proinflammatory and neurotoxic blood-
derived factors into the brain parenchyma. The BBB is damaged in Alzheimer's disease …
derived factors into the brain parenchyma. The BBB is damaged in Alzheimer's disease …
Brain-specific lipoprotein receptors interact with astrocyte derived apolipoprotein and mediate neuron-glia lipid shuttling
Lipid shuttling between neurons and glia contributes to the development, function, and
stress responses of the nervous system. To understand how a neuron acquires its lipid …
stress responses of the nervous system. To understand how a neuron acquires its lipid …