Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …

Vascularization of 3D models represents a major challenge of tissue engineering and a key
prerequisite for their clinical and industrial application. The use of prevascularized models …

Arterial thrombosis is the main instigating factor of heart attacks and strokes, which result in
over 14 million deaths worldwide every year. The mechanism of thrombosis involves factors …

The development of organs-on-chip (OoC) has revolutionized in vitro cell-culture
experiments by allowing a better mimicry of human physiology and pathophysiology that has …

The vascular system is one of the first to develop during embryogenesis and is essential for
all organs and tissues in our body to develop and function. It has many essential roles …

Neuroblastoma is an extracranial solid tumor which develops in early childhood and still has
a poor prognosis. One strategy to increase cure rates is the identification of patient-specific …

Understanding complex cell–cell interactions and physiological microenvironments is critical
for the development of new therapies for treating human diseases. Current animal models …

Cells actively interact with their microenvironment, constantly sensing and modulating
biochemical and biophysical signals. Blood comprises a variety of non-adherent cells that …

To evaluate the relationship between wall shear stress (WSS) magnitude and cerebral
aneurysm rupture and provide new insight into the disparate computational fluid dynamics …

In vivo, cells of the vascular system are subjected to various mechanical stimuli and have
demonstrated the ability to adapt their behavior via mechanotransduction. Recent advances …