Targeting oncogenic signaling in mutant FLT3 acute myeloid leukemia: the path to least resistance
The identification of recurrent driver mutations in genes encoding tyrosine kinases has
resulted in the development of molecularly-targeted treatment strategies designed to …
resulted in the development of molecularly-targeted treatment strategies designed to …
Post‐ejaculatory modifications to sperm (PEMS)
Mammalian sperm must spend a minimum period of time within a female reproductive tract
to achieve the capacity to fertilize oocytes. This phenomenon, termed sperm 'capacitation' …
to achieve the capacity to fertilize oocytes. This phenomenon, termed sperm 'capacitation' …
Global profiling of the proteomic changes associated with the post-testicular maturation of mouse spermatozoa
Spermatozoa acquire fertilization potential during passage through a highly specialized
region of the extratesticular ductal system known as the epididymis. In the absence of de …
region of the extratesticular ductal system known as the epididymis. In the absence of de …
Acrylamide modulates the mouse epididymal proteome to drive alterations in the sperm small non-coding RNA profile and dysregulate embryo development
Paternal exposure to environmental stressors elicits distinct changes to the sperm sncRNA
profile, modifications that have significant post-fertilization consequences. Despite this …
profile, modifications that have significant post-fertilization consequences. Despite this …
Mass spectrometry reveals distinct proteomic profiles in high-and low-quality stallion spermatozoa
The horse breeding industry relies upon optimal stallion fertility. Conventional sperm
assessments provide limited information regarding ejaculate quality and are not individually …
assessments provide limited information regarding ejaculate quality and are not individually …
ProAKAP4 protein marker: Towards a functional approach to male fertility
S Carracedo, L Briand-Amirat… - Animal Reproduction …, 2022 - Elsevier
Spermatozoa are highly differentiated cells whose ultimate function is fertilization to
successfully transfer the male genome. This achievement relies on the expression …
successfully transfer the male genome. This achievement relies on the expression …
The future of biomarkers in veterinary medicine: emerging approaches and associated challenges
Simple Summary In this review we seek to outline the role of new technologies in biomarker
discovery, particularly within the veterinary field and with an emphasis on 'omics', as well as …
discovery, particularly within the veterinary field and with an emphasis on 'omics', as well as …
Comparative proteomics and phosphoproteomics analysis reveal the possible breed difference in yorkshire and duroc boar spermatozoa
Y Xu, Q Han, C Ma, Y Wang, P Zhang, C Li… - Frontiers in Cell and …, 2021 - frontiersin.org
Sperm cells are of unique elongated structure and function, the development of which is
tightly regulated by the existing proteins and the posttranslational modifications (PTM) of …
tightly regulated by the existing proteins and the posttranslational modifications (PTM) of …
Time‐resolved proteomic profiling of cigarette smoke‐induced experimental chronic obstructive pulmonary disease
Background and objective Chronic obstructive pulmonary disease (COPD) is the third
leading cause of illness and death worldwide. Current treatments aim to control symptoms …
leading cause of illness and death worldwide. Current treatments aim to control symptoms …
Elucidation of the protein composition of mouse seminal vesicle fluid
The seminal vesicles are male accessory sex glands that contribute the major portion of the
seminal plasma in which mammalian spermatozoa are bathed during ejaculation. In …
seminal plasma in which mammalian spermatozoa are bathed during ejaculation. In …