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[HTML][HTML] β-Lactamases and β-Lactamase Inhibitors in the 21st Century
The β-lactams retain a central place in the antibacterial armamentarium. In Gram-negative
bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β …
bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β …
Advances and challenges in time-resolved macromolecular crystallography
BACKGROUND Conformational changes are essential for the correct functioning of
biological macromolecules. Time-resolved x-ray crystallography extends an extremely …
biological macromolecules. Time-resolved x-ray crystallography extends an extremely …
Ultracompact 3D microfluidics for time-resolved structural biology
To advance microfluidic integration, we present the use of two-photon additive
manufacturing to fold 2D channel layouts into compact free-form 3D fluidic circuits with …
manufacturing to fold 2D channel layouts into compact free-form 3D fluidic circuits with …
Time-resolved serial femtosecond crystallography at the European XFEL
Abstract The European XFEL (EuXFEL) is a 3.4-km long X-ray source, which produces
femtosecond, ultrabrilliant and spatially coherent X-ray pulses at megahertz (MHz) repetition …
femtosecond, ultrabrilliant and spatially coherent X-ray pulses at megahertz (MHz) repetition …
[HTML][HTML] Recent results in time resolved serial femtosecond crystallography at XFELs
Highlights•Time-resolved serial femtosecond crystallography (tr-SFX) probes structure and
function in each sample.•X-ray free electron lasers (XFELS) provide atomic and electronic …
function in each sample.•X-ray free electron lasers (XFELS) provide atomic and electronic …
XFELs for structure and dynamics in biology
JCH Spence - IUCrJ, 2017 - journals.iucr.org
The development and application of the free-electron X-ray laser (XFEL) to structure and
dynamics in biology since its inception in 2009 are reviewed. The research opportunities …
dynamics in biology since its inception in 2009 are reviewed. The research opportunities …
Enzyme intermediates captured “on the fly” by mix-and-inject serial crystallography
Background Ever since the first atomic structure of an enzyme was solved, the discovery of
the mechanism and dynamics of reactions catalyzed by biomolecules has been the key goal …
the mechanism and dynamics of reactions catalyzed by biomolecules has been the key goal …
Short-wavelength free-electron laser sources and science: a review
EA Seddon, JA Clarke, DJ Dunning… - Reports on Progress …, 2017 - iopscience.iop.org
This review is focused on free-electron lasers (FELs) in the hard to soft x-ray regime. The
aim is to provide newcomers to the area with insights into: the basic physics of FELs, the …
aim is to provide newcomers to the area with insights into: the basic physics of FELs, the …
[HTML][HTML] Observation of substrate diffusion and ligand binding in enzyme crystals using high-repetition-rate mix-and-inject serial crystallography
Here, we illustrate what happens inside the catalytic cleft of an enzyme when substrate or
ligand binds on single-millisecond timescales. The initial phase of the enzymatic cycle is …
ligand binds on single-millisecond timescales. The initial phase of the enzymatic cycle is …
Sample delivery for serial crystallography at free-electron lasers and synchrotrons
ML Grünbein, G Nass Kovacs - Biological Crystallography, 2019 - journals.iucr.org
The high peak brilliance and femtosecond pulse duration of X-ray free-electron lasers
(XFELs) provide new scientific opportunities for experiments in physics, chemistry and …
(XFELs) provide new scientific opportunities for experiments in physics, chemistry and …