Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused
by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and …

Intermuscular adipose tissue (IMAT) is a distinct adipose depot described in early reports as
a 'fatty replacement'or 'muscle fat infiltration'that was linked to ageing and neuromuscular …

For many years, cardiovascular disease (CVD) has been the leading cause of death around
the world. Often associated with CVD are comorbidities such as obesity, abnormal lipid …

Globally, the number of people with diabetes mellitus has quadrupled in the past three
decades, and diabetes mellitus is the ninth major cause of death. About 1 in 11 adults …

NAFLD is closely linked with hepatic insulin resistance. Accumulation of hepatic
diacylglycerol activates PKC-ε, impairing insulin receptor activation and insulin-stimulated …

Diabetes mellitus is a significant clinical and therapeutic problem because it can lead to
serious long-term complications. Its pathogenesis is not fully understood, but there are …

Childhood obesity with its growing prevalence worldwide presents one of the most important
health challenges nowadays. Multiple mechanisms are involved in the development of this …

Resistance to insulin is a pathophysiological state related to the decreased response of
peripheral tissues to the insulin action, hyperinsulinemia and raised blood glucose levels …

Insulin resistance arises when the nutrient storage pathways evolved to maximize efficient
energy utilization are exposed to chronic energy surplus. Ectopic lipid accumulation in liver …

Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …