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Recent progress in non-native nucleic acid modifications
While Nature harnesses RNA and DNA to store, read and write genetic information, the
inherent programmability, synthetic accessibility and wide functionality of these nucleic acids …
inherent programmability, synthetic accessibility and wide functionality of these nucleic acids …
The eightfold path to non-enzymatic RNA replication
The first RNA World models were based on the concept of an RNA replicase-a ribozyme that
was a good enough RNA polymerase that it could catalyze its own replication. Although …
was a good enough RNA polymerase that it could catalyze its own replication. Although …
Synthetic genetic polymers capable of heredity and evolution
Genetic information storage and processing rely on just two polymers, DNA and RNA, yet
whether their role reflects evolutionary history or fundamental functional constraints is …
whether their role reflects evolutionary history or fundamental functional constraints is …
Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor
The pre-RNA world hypothesis postulates that RNA was preceded in the evolution of life by
a simpler genetic material, but it is not known if such systems can fold into structures capable …
a simpler genetic material, but it is not known if such systems can fold into structures capable …
Nuclear genomic sequences reveal that polar bears are an old and distinct bear lineage
Recent studies have shown that the polar bear matriline (mitochondrial DNA) evolved from a
brown bear lineage since the late Pleistocene, potentially indicating rapid speciation and …
brown bear lineage since the late Pleistocene, potentially indicating rapid speciation and …
Xenobiology: a new form of life as the ultimate biosafety tool
Synthetic biologists try to engineer useful biological systems that do not exist in nature. One
of their goals is to design an orthogonal chromosome different from DNA and RNA, termed …
of their goals is to design an orthogonal chromosome different from DNA and RNA, termed …
The XNA world: progress towards replication and evolution of synthetic genetic polymers
Life's diversity is built on the wide range of properties and functions that can be encoded in
natural biopolymers such as polypeptides and nucleic acids. However, despite their …
natural biopolymers such as polypeptides and nucleic acids. However, despite their …
Towards XNA nanotechnology: new materials from synthetic genetic polymers
Nucleic acids display remarkable properties beyond information storage and propagation.
The well-understood base pairing rules have enabled nucleic acids to be assembled into …
The well-understood base pairing rules have enabled nucleic acids to be assembled into …
Chemoselective multicomponent one-pot assembly of purine precursors in water
The recent development of a sequential, high-yielding route to activated pyrimidine
nucleotides, under conditions thought to be prebiotic, is an encouraging step toward the …
nucleotides, under conditions thought to be prebiotic, is an encouraging step toward the …
Expanding the Horizon of the Xeno Nucleic Acid Space: Threose Nucleic Acids with Increased Information Storage
Xeno nucleic acids (XNAs) constitute a class of synthetic nucleic acid analogues
characterized by distinct, non-natural modifications within the tripartite structure of the …
characterized by distinct, non-natural modifications within the tripartite structure of the …