Necroptosis is a form of programmed necrosis that is mediated by various cytokines and
pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes …

This comprehensive review explores the intricate mechanisms of PANoptosis and its
implications in cancer. PANoptosis, a convergence of apoptosis, pyroptosis, and …

Ischemia-reperfusion injury (IRI) is the outcome of an inflammatory process that is triggered
when an organ undergoes a transient reduction or cessation of blood flow, followed by re …

Thrombolytic therapy and revascularization strategies create a complete recanalization of
the occluded epicardial coronary artery in patients with myocardial infarction (MI). However …

The death of cardiomyocytes either through apoptosis or necroptosis is the pathological
feature of cardiac ischemia-reperfusion (I/R) injury. Phosphoglycerate mutase 5 (PGAM5), a …

The plant homolog of vertebrate necroptosis inducer mixed-lineage kinase domain-like
(MLKL) contributes to downstream steps in Toll-interleukin-1 receptor domain NLR (TNL) …

Recently, necroptosis, as a programmed cell death pathway, has drawn much attention as it
has been implicated in multiple pathologies, especially in the field of inflammatory diseases …

Necroptotic cell death is mediated by the most terminal known effector of the pathway,
MLKL. Precisely how phosphorylation of the MLKL pseudokinase domain activation loop by …

The ancestral origins of the lytic cell death mode, necroptosis, lie in host defense. However,
the dysregulation of necroptosis in inflammatory diseases has led to widespread interest in …

Phosphorylation of the MLKL pseudokinase by the RIPK3 kinase leads to MLKL
oligomerization, translocation to, and permeabilization of, the plasma membrane to induce …