Significance: Metabolic syndrome is a frequent precursor of type 2 diabetes mellitus (T2D), a
disease that currently affects∼ 8% of the adult population worldwide. Pancreatic beta-cell …

The pathogenic mutation in Friedreich's ataxia (FRDA) is a homozygous guanine-adenine-
adenine (GAA) trinucleotide repeat expansion on chromosome 9q13 that causes a …

Over the last few decades, many different groups have been engaged in studies of new
roles for mitochondria, particularly the coupling of alterations in the redox pathway with the …

The central importance of iron in the pathophysiology of disease is derived from the ease
with which iron is reversibly oxidized and reduced. This property, while essential for its …

Abstract d-Glucosamine (GlcN) is a freely available and commonly used dietary supplement
potentially promoting cartilage health in humans, which also acts as an inhibitor of …

Iron has emerged as a significant cause of neurotoxicity in several neurodegenerative
conditions, including Alzheimer's disease (AD), Parkinson's disease (PD), sporadic …

More than 20 syndromes among the significant and increasing number of degenerative
diseases of neuronal tissues are known to be associated with diabetes mellitus, increased …

Objective: The marked increase in the prevalence of obesity in the United States has
recently been attributed to the increased fructose consumption. To determine if and how …

Abstract Iron–sulfur (Fe–S) clusters are ancient, ubiquitous cofactors composed of iron and
inorganic sulfur. The combination of the chemical reactivity of iron and sulfur, together with …

Although most of the proposed beneficial effects of fiber consumption have been attributed
to viscous and gel-forming properties of soluble fiber, it is mainly insoluble cereal fiber and …