The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

Cell death represents a basic biological paradigm that governs outcomes and long-term
sequelae in almost every hepatic disease condition. Acute liver failure is characterized by …

Various forms of cell death have been identified over the last decades with each relying on a
different subset of proteins for the activation and execution of their respective pathway (s). In …

Apoptosis is a highly regulated process of cell deletion and plays a fundamental role in the
maintenance of tissue homeostasis in the adult organism. Numerous studies in recent years …

Abstract Treatment of inflammatory diseases today is largely based on interrupting the
synthesis or action of mediators that drive the host's response to injury. Non-steroidal anti …

Prompt removal of unwanted cells, such as senescent, damaged, genetically mutated, or
virus infected cells, is crucial for the maintenance of liver health. This process is naturally …

The study of hepatic fibrosis, or scarring in response to chronic liver injury, has witnessed
tremendous progress in the past two decades. Clarification of the cellular sources of scar …

Patients with sepsis are immune compromised, as evidenced by their failure to clear their
primary infection and their propensity to develop secondary infections with pathogens that …

Hepatic ischemia-reperfusion injury is a major cause of liver transplant failure, and is of
increasing significance due to increased use of expanded criteria livers for transplantation …

Pathological increases in cell death in the liver as well as in peripheral tissues has emerged
as an important mechanism involved in the development and progression of nonalcoholic …