Autophagy and exercise: current insights and future research directions

J Botella, CS Shaw, DJ Bishop - International Journal of Sports …, 2024 - thieme-connect.com
Autophagy is a cellular process by which proteins and organelles are degraded inside the
lysosome. Exercise is known to influence the regulation of autophagy in skeletal muscle …

[HTML][HTML] Exercise-driven cellular autophagy: A bridge to systematic wellness

XH Zhou, YX Luo, XQ Yao - Journal of Advanced Research, 2025 - Elsevier
Background Exercise enhances health by supporting homeostasis, bolstering defenses, and
aiding disease recovery. It activates autophagy, a conserved cellular process essential for …

Effects of gallic acid and physical training on liver damage, force, and anxiety in obese mice: hepatic modulation of Sestrin 2 (SESN2) and PGC-α expression

JN Sousa, BV de Oliveira Sousa, EP Dos Santos… - Gene, 2024 - Elsevier
Obesity and overweight are multifactorial diseases affecting more than one-third of the
world's population. Physical inactivity contributes to a positive energy balance and the onset …

The effects of diet composition and chronic obesity on muscle growth and function

LGO de Sousa, AG Marshall… - Journal of Applied …, 2021 - journals.physiology.org
Diet-induced obesity (DIO) is associated with glucose intolerance, insulin resistance (IR),
and an increase in intramyocellular lipids (IMCL), which may lead to disturbances in glucose …

[HTML][HTML] Exercise and training regulation of autophagy markers in human and rat skeletal muscle

J Botella, NA Jamnick, C Granata, AJ Genders… - International Journal of …, 2022 - mdpi.com
Autophagy is a key intracellular mechanism by which cells degrade old or dysfunctional
proteins and organelles. In skeletal muscle, evidence suggests that exercise increases …

A single bout of exhaustive treadmill exercise increased AMPK activation associated with enhanced autophagy in mice skeletal muscle

P Wang, CG Li, X Zhou, D Cui, T Ouyang… - Clinical and …, 2022 - Wiley Online Library
Previous studies reported inconsistent findings on autophagy activation in skeletal muscles
after acute exercise. In this study, we investigated the effect of a single bout of exhaustive …

[HTML][HTML] The effects of exercise and restriction of sugar-sweetened beverages on muscle function and autophagy regulation in high-fat high-sucrose-fed obesity mice

D Zhang, JH Lee, HE Shin, SE Kwak… - Diabetes & …, 2021 - synapse.koreamed.org
Background Autophagy maintains muscle mass and healthy skeletal muscles. Several
recent studies have associated sugar-sweetened beverage (SSB) consumption with …

Restoring Autophagy by Exercise Ameliorates Insulin Resistance Partly via Calcineurin‐Driven TFEB Nuclear Translocation

P Wang, J Li, CG Li, X Zhou, X Chen… - Clinical and …, 2025 - Wiley Online Library
Exercise activates autophagy and lysosome system in skeletal muscle, which are known to
play an important role in metabolic adaptation. However, the mechanism of exercise …

Differential protein metabolism and regeneration in gastrocnemius muscles in high-fat diet fed mice and pre-hibernation daurian ground squirrels: a comparison …

X Yan, Q Niu, X Gao, S Shen, N He, H Wang… - Zoological …, 2021 - pmc.ncbi.nlm.nih.gov
We focused on pathological obesity induced by excessive fat intake (nutritional obesity) in
non-hibernator and healthy obesity due to pre-hibernation (PRE) fat storage in hibernator to …

Exercise and training regulation of autophagy markers in human and rodent skeletal muscle

J Botella, NA Jamnick, C Granata, AJ Genders, E Perri… - bioRxiv, 2021 - biorxiv.org
Autophagy is a key intracellular mechanism by which cells degrade old or dysfunctional
proteins and organelles. In skeletal muscle, evidence suggests that exercise increases …