Metastasis has long been understood to lead to the overwhelming majority of cancer-related
deaths. However, our understanding of the metastatic process, and thus our ability to …

Recent studies on mutations in cancer genomes have distinguished driver mutations from
passenger mutations, which occur as byproducts of cancer development. The cancer …

Metastasis is the major cause of cancer-related deaths due to the lack of effective therapies.
Emerging evidence suggests that certain epigenetic and transcriptional regulators drive …

Cancer was thought to be caused solely by genetic mutations in oncogenes and tumor
suppressor genes. In the last 35 years, however, epigenetic changes have been …

In recent years, many studies have shown that histone methylation plays an important role in
maintaining the active and silent state of gene expression in human diseases. The Jumonji …

Histone methylation, one of the most prominent epigenetic modifications, plays a vital role in
gene transcription, and aberrant histone methylation levels cause tumorigenesis. Histone …

The role of the transcription factor NF-κB in sha** the cancer microenvironment is
becoming increasingly clear. Inflammation alters the activity of enzymes that modulate NF …

Recent studies have delineated cancer-type-specific roles of histone 3 lysine 27 (H3K27)
demethylase KDM6B/JMJD3 depending on its H3K27 demethylase activity. Here we show …

Malignant melanoma is the most deadly form of skin cancer. It originates from melanocytic
cells and can also arise at other body sites. Early diagnosis and appropriate medical care …

Simple Summary Regulation of gene expression is important for appropriate cell
development but can also lead to inappropriate cell transformation resulting in cancer …