The rapid development of precision medicine in recent years has started to challenge
diagnostic pathology with respect to its ability to analyze histological images and …

Cancer development is driven by the accumulation of alterations affecting the structure and
function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic …

Histomorphology has been a mainstay of cancer diagnosis in anatomic pathology for many
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …

Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in
childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often …

Precision in the diagnosis of diverse central nervous system (CNS) tumor types is crucial for
optimal treatment. DNA methylation profiles, which capture the methylation status of …

In the 5th edition of the WHO CNS tumor classification (CNS5, 2021), multiple molecular
characteristics became essential diagnostic criteria for many additional CNS tumor types …

The diagnosis of sinonasal tumors is challenging due to a heterogeneous spectrum of
various differential diagnoses as well as poorly defined, disputed entities such as sinonasal …

INFORM is a prospective, multinational registry gathering clinical and molecular data of
relapsed, progressive, or high-risk pediatric patients with cancer. This report describes long …

Soft tissue sarcomas (STS) are rare and diverse mesenchymal cancers with limited
treatment options. Here we undertake comprehensive proteomic profiling of tumour …

The utility of cancer whole genome and transcriptome sequencing (cWGTS) in oncology is
increasingly recognized. However, implementation of cWGTS is challenged by the need to …