Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)
BO Roep, S Thomaidou, R van Tienhoven… - Nature Reviews …, 2021 - nature.com
Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …
Type 1 diabetes: etiology, immunology, and therapeutic strategies
TL Van Belle, KT Coppieters… - Physiological …, 2011 - journals.physiology.org
Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of
the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We …
the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We …
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
KT Coppieters, F Dotta, N Amirian… - Journal of Experimental …, 2012 - rupress.org
A direct association of islet-autoreactive T cells with β cell destruction in human pancreatic
islets from type 1 diabetes (T1D) patients has never been demonstrated, and little is known …
islets from type 1 diabetes (T1D) patients has never been demonstrated, and little is known …
Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients
F Dotta, S Censini, AGS van Halteren… - Proceedings of the …, 2007 - National Acad Sciences
Type 1 diabetes is characterized by T cell-mediated autoimmune destruction of pancreatic β
cells. Several studies have suggested an association between Coxsackie enterovirus …
cells. Several studies have suggested an association between Coxsackie enterovirus …
Oxidative stress leads to β-cell dysfunction through loss of β-cell identity
Pancreatic β-cell failure is a critical event in the onset of both main types of diabetes mellitus
but underlying mechanisms are not fully understood. β-cells have low anti-oxidant capacity …
but underlying mechanisms are not fully understood. β-cells have low anti-oxidant capacity …
TNF receptor 2 pathway: drug target for autoimmune diseases
D Faustman, M Davis - Nature reviews Drug discovery, 2010 - nature.com
Although drug development has advanced for autoimmune diseases, many current
therapies are hampered by adverse effects and the frequent destruction or inactivation of …
therapies are hampered by adverse effects and the frequent destruction or inactivation of …
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
S Nejentsev, JMM Howson, NM Walker, J Szeszko… - Nature, 2007 - nature.com
The major histocompatibility complex (MHC) on chromosome 6 is associated with
susceptibility to more common diseases than any other region of the human genome …
susceptibility to more common diseases than any other region of the human genome …
Cross-priming in health and disease
Cross-priming is an important mechanism to activate cytotoxic T lymphocytes (CTLs) for
immune defence against viruses and tumours. Although it was discovered more than 25 …
immune defence against viruses and tumours. Although it was discovered more than 25 …
Kv1. 3 channels are a therapeutic target for T cell-mediated autoimmune diseases
Autoreactive memory T lymphocytes are implicated in the pathogenesis of autoimmune
diseases. Here we demonstrate that disease-associated autoreactive T cells from patients …
diseases. Here we demonstrate that disease-associated autoreactive T cells from patients …
Human islet T cells are highly reactive to preproinsulin in type 1 diabetes
AM Anderson, LG Landry… - Proceedings of the …, 2021 - National Acad Sciences
Cytotoxic CD8 T lymphocytes play a central role in the tissue destruction of many
autoimmune disorders. In type 1 diabetes (T1D), insulin and its precursor preproinsulin are …
autoimmune disorders. In type 1 diabetes (T1D), insulin and its precursor preproinsulin are …