Current advance of nanotechnology in diagnosis and treatment for malignant tumors

B Wang, S Hu, Y Teng, J Chen, H Wang, Y Xu… - … and Targeted Therapy, 2024 - nature.com
Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary
field that is garnering a lot of interest and investigation. Nanomedicine shows great potential …

Noncoding RNA therapeutics—challenges and potential solutions

M Winkle, SM El-Daly, M Fabbri, GA Calin - Nature reviews Drug …, 2021 - nature.com
Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …

Where should siRNAs go: applicable organs for siRNA drugs

I Ahn, CS Kang, J Han - Experimental & Molecular Medicine, 2023 - nature.com
RNA interference mediated by small interfering RNAs (siRNAs) has been exploited for the
development of therapeutics. siRNAs can be a powerful therapeutic tool because the …

[HTML][HTML] A historical review of brain drug delivery

WM Pardridge - Pharmaceutics, 2022 - mdpi.com
The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …

Glioblastoma therapy: Past, present and future

E Obrador, P Moreno-Murciano… - International journal of …, 2024 - mdpi.com
Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …

Clinical translation of gold nanoparticles

R Zhang, F Kiessling, T Lammers… - Drug delivery and …, 2023 - Springer
Gold nanoparticles display unique physicochemical features, which can be useful for
therapeutic purposes. After two decades of preclinical progress, gold nanoconstructs are …

NIR-II light-driven genetically engineered exosome nanocatalysts for efficient phototherapy against glioblastoma

X Fang, R Gong, D Yang, C Li, Y Zhang… - Journal of the …, 2024 - ACS Publications
Glioblastoma (GBM) poses a significant therapeutic challenge due to its invasive nature and
limited drug penetration through the blood–brain barrier (BBB). In response, here we …

Materials engineering strategies for cancer vaccine adjuvant development

X Zhang, B Yang, Q Ni, X Chen - Chemical Society Reviews, 2023 - pubs.rsc.org
Cancer vaccines have emerged as a powerful new tool for cancer immunotherapy.
Adjuvants are vaccine ingredients that enhance the strength, velocity, and duration of the …

Cancer chemotherapy resistance: Mechanisms and recent breakthrough in targeted drug delivery

F Davodabadi, SF Sajjadi, M Sarhadi… - European Journal of …, 2023 - Elsevier
Conventional chemotherapy, one of the most widely used cancer treatment methods, has
serious side effects, and usually results in cancer treatment failure. Drug resistance is one of …

[HTML][HTML] Applications and safety of gold nanoparticles as therapeutic devices in clinical trials

L Yao, D Bojic, M Liu - Journal of Pharmaceutical Analysis, 2023 - Elsevier
Use of gold nanoparticles (GNPs) in medicine is an emerging field of translational research
with vast clinical implications and exciting therapeutic potential. However, the safety of using …