Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …

Chromatin provides both a means to accommodate a large amount of genetic material in a
small space and a means to package the same genetic material in different chromatin states …

Chromatin remodelling complexes evict, slide, insert or replace nucleosomes, which
represent an intrinsic barrier for access to DNA. These remodellers function in most aspects …

Macromolecular assemblies that regulate chromatin structure using the energy of ATP
hydrolysis have critical roles in development, cancer, and stem cell biology. The ATPases of …

The packaging of chromosomal DNA by nucleosomes condenses and organizes the
genome, but occludes many regulatory DNA elements. However, this constraint also allows …

Nearly all essential nuclear processes act on DNA packaged into arrays of nucleosomes.
However, our understanding of how these processes (for example, DNA replication, RNA …

Inheritance and maintenance of the DNA sequence and its organization into chromatin are
central for eukaryotic life. To orchestrate DNA-replication and-repair processes in the context …

HP1 proteins are central to the assembly and spread of heterochromatin containing histone
H3K9 methylation. The chromodomain (CD) of HP1 proteins specifically recognizes the …

Understanding how the genome is structurally organized as chromatin is essential for
understanding its function. Here, we review recent developments that allowed the …

Through epigenetic modifications, specific long-term phenotypic consequences can arise
from environmental influence on slowly evolving genomic DNA. Heritable epigenetic …