Hantavirus in humans: a review of clinical aspects and management

PA Vial, M Ferrés, C Vial, J Klingström… - The Lancet Infectious …, 2023 - thelancet.com
Hantavirus infections are part of the broad group of viral haemorrhagic fevers. They are also
recognised as a distinct model of an emergent zoonotic infection with a global distribution …

[HTML][HTML] Neutralization determinants on Poxviruses

V Riccardo, GC Pablo - Viruses, 2023 - mdpi.com
Smallpox was a highly contagious disease caused by the variola virus. The disease affected
millions of people over thousands of years and variola virus ranked as one of the deadliest …

Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody

E Mittler, A Serris, ES Esterman, C Florez… - Science translational …, 2023 - science.org
Emerging rodent-borne hantaviruses cause severe diseases in humans with no approved
vaccines or therapeutics. We recently isolated a monoclonal broadly neutralizing antibody …

[HTML][HTML] Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlap** regions on glycoprotein GP38

OS Shin, SR Monticelli, CK Hjorth, V Hornet, M Doyle… - Cell reports, 2024 - cell.com
Crimean-Congo hemorrhagic fever virus can cause lethal disease in humans yet there are
no approved medical countermeasures. Viral glycoprotein GP38, exclusive to Nairoviridae …

Mechanistic basis for potent neutralization of Sin Nombre hantavirus by a human monoclonal antibody

R Stass, TB Engdahl, NS Chapman, RM Wolters… - Nature …, 2023 - nature.com
Rodent-borne hantaviruses are prevalent worldwide and upon spillover to human
populations, cause severe disease for which no specific treatment is available. A potent …

Characterization of a panel of cross-reactive Hantavirus Nucleocapsid protein-specific monoclonal antibodies

A Avižinienė, I Kučinskaitė-Kodzė… - Viruses, 2023 - mdpi.com
Hantaviruses are emerging pathogens with a worldwide distribution that can cause life-
threatening diseases in humans. Monoclonal antibodies (MAbs) against hantavirus …

The Adaptive Immune Response against Bunyavirales

R Alatrash, BB Herrera - Viruses, 2024 - mdpi.com
The Bunyavirales order includes at least fourteen families with diverse but related viruses,
which are transmitted to vertebrate hosts by arthropod or rodent vectors. These viruses are …

Phase 1 clinical trial of Hantaan and Puumala virus DNA vaccines delivered by needle-free injection

JW Hooper, SA Kwilas, M Josleyn, S Norris, JN Hutter… - npj Vaccines, 2024 - nature.com
Hantaan virus (HTNV) and Puumala virus (PUUV) are pathogenic zoonoses found in Asia
and Europe, respectively. We conducted a randomized Phase 1 clinical trial of individual …

A pan-orthohantavirus human lung xenograft mouse model and its utility for preclinical studies

M Rissmann, D Noack, TM Spliethof, VP Vaes… - PLoS …, 2025 - journals.plos.org
Orthohantaviruses are emerging zoonotic viruses that can infect humans via the respiratory
tract. There is an unmet need for an in vivo model to study infection of different …