Hybrid modelling of biological systems: current progress and future prospects

F Liu, M Heiner, D Gilbert - Briefings in Bioinformatics, 2022 - academic.oup.com
Integrated modelling of biological systems is becoming a necessity for constructing models
containing the major biochemical processes of such systems in order to obtain a holistic …

A holonic framework for managing the sustainable supply chain in emerging economies with smart connected metabolism

A Martín-Gómez, F Aguayo-González… - Resources, Conservation …, 2019 - Elsevier
Since their origins, human societies have integrated into the natural environment, where
social metabolism that identified the interactions between society and nature was …

[HTML][HTML] Reliability and efficiency evaluation of a community pharmacy dispensing process using a coloured Petri-net approach

M Naybour, R Remenyte-Prescott, MJ Boyd - Reliability Engineering & …, 2019 - Elsevier
It has been estimated that European customers visit community pharmacies to access
essential primary healthcare around 46 million times every day. Studies of dispensing error …

Spatial quorum sensing modelling using coloured hybrid Petri nets and simulative model checking

D Gilbert, M Heiner, L Ghanbar, J Chodak - BMC bioinformatics, 2019 - Springer
Background Quorum sensing drives biofilm formation in bacteria in order to ensure that
biofilm formation only occurs when colonies are of a sufficient size and density. This spatial …

Automatic construction of Petri net models for computational simulations of molecular interaction network

X Lin, X Chang, Y Zhang, Z Gao, X Chi - NPJ Systems Biology and …, 2024 - nature.com
Petri nets are commonly applied in modeling biological systems. However, construction of a
Petri net model for complex biological systems is often time consuming, and requires …

A Petri nets-based framework for whole-cell modeling

F Liu, G Assaf, M Chen, M Heiner - Biosystems, 2021 - Elsevier
Whole-cell modeling aims to incorporate all main genes and processes, and their
interactions of a cell in one model. Whole-cell modeling has been regarded as the central …

EB-DEVS: A formal framework for modeling and simulation of emergent behavior in dynamic complex systems

D Foguelman, P Henning, A Uhrmacher… - Journal of Computational …, 2021 - Elsevier
Emergent behavior is a key feature defining a system under study as a complex system.
Simulation has been recognized as the only way to deal with the study of the emergence of …

Modeling and analyzing transmission of infectious diseases using generalized stochastic petri nets

L Peng, P **e, Z Tang, F Liu - Applied Sciences, 2021 - mdpi.com
Some infectious diseases such as COVID-19 have the characteristics of long incubation
period, high infectivity during the incubation period, and carriers with mild or no symptoms …

From epidemic to pandemic modelling

S Connolly, D Gilbert, M Heiner - Frontiers in Systems Biology, 2022 - frontiersin.org
We present a methodology for systematically extending epidemic models to multilevel and
multiscale spatio-temporal pandemic ones. Our approach builds on the use of coloured …

[HTML][HTML] Nets-within-nets for modeling emergent patterns in ontogenetic processes

R Bardini, A Benso, G Politano, S Di Carlo - Computational and Structural …, 2021 - Elsevier
Ontogenesis is the development of an organism from its earliest stage to maturity, including
homeostasis maintenance throughout adulthood despite environmental perturbations …