[HTML][HTML] Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria

RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

Small RNAs, large networks: posttranscriptional regulons in gram-negative bacteria

K Papenfort, S Melamed - Annual review of microbiology, 2023 - annualreviews.org
Small regulatory RNA (sRNAs) are key mediators of posttranscriptional gene control in
bacteria. Assisted by RNA-binding proteins, a single sRNA often modulates the expression …

Biofilms by bacterial human pathogens: Clinical relevance-development, composition and regulation-therapeutical strategies

A Schulze, F Mitterer, JP Pombo, S Schild - Microbial Cell, 2021 - pmc.ncbi.nlm.nih.gov
Notably, bacterial biofilm formation is increasingly recognized as a passive virulence factor
facilitating many infectious disease processes. In this review we will focus on bacterial …

An RNA sponge controls quorum sensing dynamics and biofilm formation in Vibrio cholerae

M Huber, A Lippegaus, S Melamed, M Siemers… - Nature …, 2022 - nature.com
Small regulatory RNAs (sRNAs) acting in concert with the RNA chaperone Hfq are prevalent
in many bacteria and typically act by base-pairing with multiple target transcripts. In the …

The role of RNA regulators, quorum sensing and c‐di‐GMP in bacterial biofilm formation

M Condinho, B Carvalho, A Cruz, SN Pinto… - FEBS Open …, 2023 - Wiley Online Library
Biofilms provide an ecological advantage against many environmental stressors, such as pH
and temperature, making it the most common life‐cycle stage for many bacteria. These …

Phenotypic heterogeneity in bacterial quorum sensing systems

V Bettenworth, B Steinfeld, H Duin, K Petersen… - Journal of Molecular …, 2019 - Elsevier
Quorum sensing is usually thought of as a collective behavior in which all members of a
population partake. However, over the last decade, several reports of phenotypic …

Salicylic acid stabilizes Staphylococcus aureus biofilm by impairing the agr quorum-sensing system

C Dotto, A Lombarte Serrat, M Ledesma, C Vay… - Scientific Reports, 2021 - nature.com
Salicylic acid (SAL) has recently been shown to induce biofilm formation in Staphylococcus
aureus and to affect the expression of virulence factors. This study was aimed to investigate …

Regulatory small RNA Qrr2 is expressed independently of sigma factor-54 and can function as the sole Qrr small RNA to control quorum sensing in Vibrio …

JG Tague, J Hong, SS Kalburge… - Journal of bacteriology, 2022 - journals.asm.org
Bacterial cells alter gene expression in response to changes in population density in a
process called quorum sensing (QS). In Vibrio harveyi, LuxO, a low-cell-density activator of …

RNA-mediated control of cell shape modulates antibiotic resistance in Vibrio cholerae

N Peschek, R Herzog, PK Singh, M Sprenger… - Nature …, 2020 - nature.com
Vibrio cholerae, the cause of cholera disease, exhibits a characteristic curved rod
morphology, which promotes infectivity and motility in dense hydrogels. Periplasmic protein …

Quorum sensing going wild

M Spacapan, C Bez, V Venturi - Iscience, 2023 - cell.com
The first discovered and well-characterized bacterial quorum sensing (QS) system belongs
to Vibrio fischeri, which uses N-acyl homo-serine lactones (AHLs) for cell-cell signaling. AHL …