Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis
The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo
differentiation into osteoblasts. This differentiation process plays a crucial role in bone …
differentiation into osteoblasts. This differentiation process plays a crucial role in bone …
Functions of osteocalcin in bone, pancreas, testis, and muscle
T Komori - International journal of molecular sciences, 2020 - mdpi.com
Osteocalcin (Ocn), which is specifically produced by osteoblasts, and is the most abundant
non-collagenous protein in bone, was demonstrated to inhibit bone formation and function …
non-collagenous protein in bone, was demonstrated to inhibit bone formation and function …
Osteocalcin: a multifaceted bone-derived hormone
G Karsenty - Annual review of nutrition, 2023 - annualreviews.org
Together, loss-and gain-of-function experiments have identified the bone-derived secreted
molecule osteocalcin as a hormone with a broad reach in rodents and primates. Following …
molecule osteocalcin as a hormone with a broad reach in rodents and primates. Following …
Paracrine and endocrine actions of bone—the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts
The skeleton is a dynamic organ that is constantly remodeled. Proteins secreted from bone
cells, namely osteoblasts, osteocytes, and osteoclasts exert regulation on …
cells, namely osteoblasts, osteocytes, and osteoclasts exert regulation on …
Cytokines and abnormal glucose and lipid metabolism
J Shi, J Fan, Q Su, Z Yang - Frontiers in endocrinology, 2019 - frontiersin.org
Clear evidence indicates that cytokines, for instance, adipokines, hepatokines, inflammatory
cytokines, myokines, and osteokines, contribute substantially to the development of …
cytokines, myokines, and osteokines, contribute substantially to the development of …
The role of exercise in the interplay between myokines, hepatokines, osteokines, adipokines, and modulation of inflammation for energy substrate redistribution and …
Exercise is an effective strategy for preventing and treating obesity and its related
cardiometabolic disorders, resulting in significant loss of body fat mass, white adipose tissue …
cardiometabolic disorders, resulting in significant loss of body fat mass, white adipose tissue …
New insights into the biology of osteocalcin
Osteocalcin is among the most abundant proteins in bone and is produced exclusively by
osteoblasts. Initially believed to be an inhibitor of bone mineralization, recent studies …
osteoblasts. Initially believed to be an inhibitor of bone mineralization, recent studies …
The role of osteoblasts in energy homeostasis
Osteoblasts are specialized mesenchymal cells that synthesize bone matrix and coordinate
the mineralization of the skeleton. These cells work in harmony with osteoclasts, which …
the mineralization of the skeleton. These cells work in harmony with osteoclasts, which …
MC4R-dependent suppression of appetite by bone-derived lipocalin 2
Bone has recently emerged as a pleiotropic endocrine organ that secretes at least two
hormones, FGF23 and osteocalcin, which regulate kidney function and glucose …
hormones, FGF23 and osteocalcin, which regulate kidney function and glucose …
[HTML][HTML] Osteocalcin signaling in myofibers is necessary and sufficient for optimum adaptation to exercise
P Mera, K Laue, M Ferron, C Confavreux, J Wei… - Cell metabolism, 2016 - cell.com
Circulating levels of undercarboxylated and bioactive osteocalcin double during aerobic
exercise at the time levels of insulin decrease. In contrast, circulating levels of osteocalcin …
exercise at the time levels of insulin decrease. In contrast, circulating levels of osteocalcin …