Inflamm‐aging: an evolutionary perspective on immunosenescence

C Franceschi, M Bonafè, S Valensin… - Annals of the new …, 2000‏ - Wiley Online Library
In this paper we extend the “network theory of aging,” and we argue that a global reduction
in the capacity to cope with a variety of stressors and a concomitant progressive increase in …

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

C Franceschi, M Capri, D Monti, S Giunta… - Mechanisms of ageing …, 2007‏ - Elsevier
A large part of the aging phenotype, including immunosenescence, is explained by an
imbalance between inflammatory and anti-inflammatory networks, which results in the low …

Plasminogen activator inhibitor‐1 (PAI‐1): a key factor linking fibrinolysis and age‐related subclinical and clinical conditions

M Cesari, M Pahor, RA Incalzi - Cardiovascular therapeutics, 2010‏ - Wiley Online Library
Introduction: The close relationship existing between aging and thrombosis has growingly
been studied in this last decade. The age‐related development of a prothrombotic …

Молекулярные и физиологические механизмы старения

ВН Анисимов - 2008‏ - elibrary.ru
В монографии проанализированы основные концепции о природе старения, история
их возникновения и эволюция. Изложены современные представления о …

Inflammaging as a prodrome to Alzheimer's disease

B Giunta, F Fernandez, WV Nikolic, D Obregon… - Journal of …, 2008‏ - Springer
Recently, the term" inflammaging" was coined by Franceshci and colleagues to characterize
a widely accepted paradigm that ageing is accompanied by a low-grade chronic up …

Aging and thrombosis

WR Wilkerson, DC Sane - Seminars in thrombosis and …, 2002‏ - thieme-connect.com
Advanced age is associated with a dramatic increase in the rates of venous and arterial
thrombotic events. Increases in fibrinogen, factors VIII and IX, and other coagulation …

Hemostasis and aging

M Franchini - Critical reviews in oncology/hematology, 2006‏ - Elsevier
Many changes in the vasculature, hemostasis and endothelium, including alterations of
platelets, coagulation and fibrinolytic factors, occur during aging. While the increasing …

The genetics of exceptional human longevity

T Perls, LM Kunkel, AA Puca - Journal of the American …, 2002‏ - Wiley Online Library
There is a substantial distinction to be made between the genetics of aging and the genetics
of exceptional longevity. Twin studies suggest that the average set of genetic variations …

Hemostasis factors and aging

D Mari, R Coppola, R Provenzano - Experimental gerontology, 2008‏ - Elsevier
With advancing age, an increasing number of healthy individuals have laboratory signs of
heightened coagulation enzyme activity. Such biochemical hypercoagulability might be the …

The evolutionary theories of aging revisited–a mini-review

P Ljubuncic, AZ Reznick - Gerontology, 2009‏ - karger.com
This short review portrays the evolutionary theories of aging in the light of the existing
discoveries from genomic and molecular genetic studies on aging and longevity. At the …