Despite aging being by far the greatest risk factor for highly prevalent neurodegenerative
disorders, the molecular underpinnings of age-related brain changes are still not well …

Microglia are brain macrophages that mediate neuroinflammation and contribute to and
protect against neurodegeneration. The terminal sugar residue of all glycoproteins and …

Abstract Background Haploinsufficiency in the Gaucher disease GBA gene, which encodes
the lysosomal glucocerebrosidase GBA, and ageing represent major risk factors for …

Sialic acids, commonly found as the terminal carbohydrate on the glycocalyx of mammalian
cells, are pivotal checkpoint inhibitors of the innate immune system, particularly within the …

Gangliosides (GG s) are sialic acid‐containing glycosphingolipids (GSL s) and major
membrane components enriched on cellular surfaces. Biosynthesis of mammalian GG s …

Glycosphingolipids are important building blocks of the outer leaflet of the cell membrane.
They are continuously recycled, involving fragmentation inside lysosomes by glycosidases …

Aging is the predominant risk factor for both genetic and sporadic Parkinson's disease (PD).
The majority of PD cases are nonfamilial, and the connection between aging and PD …

Background Chronic vascular disease atherosclerosis starts with an uptake of atherogenic
modified low‐density lipoproteins (LDLs) by resident macrophages, resulting in formation of …

Sialic acids are monosaccharides that normally terminate the glycan chains of cell surface
glyco‐proteins and‐lipids in mammals, and are highly enriched in the central nervous tissue …

Epidemiological evidence links exposure to 2-ethylhexyl diphenyl phosphate (EHDPP) with
lipid metabolic disruption, typically attributed to nuclear receptors, while the role of …