All organisms growing beyond the oxygen diffusion limit critically depend on a functional
vasculature for survival. Yet blood vessels are far more than passive, uniform conduits for …

Acute myocardial infarction (MI) inflicts massive injury to the coronary microcirculation
leading to vascular disintegration and capillary rarefication in the infarct region. Tissue …

Cell-based scaffold-free therapies seek to develop in vitro organotypic three-dimensional
(3D) tissue-like surrogates, capitalising upon the inherent capacity of cells to create tissues …

Angiogenesis—the formation of new blood vessels from existing blood vessels—has drawn
significant attention in medical research. New techniques have been developed to control …

Metal ions participate in many metabolic processes in the human body, and their
homeostasis is crucial for life. In cardiovascular diseases (CVDs), the equilibriums of metal …

Despite long-term efforts for ischemia therapy, proangiogenic drugs hardly satisfy
therapy/safety/cost/mass production multiple evaluations and meanwhile with a desire to …

Exosomes are cell-derived nanovesicles, circulating in different body fluids, and acting as an
intercellular mechanism. They can be purified from culture media of different cell types and …

Fertility preservation for prepubertal boys relies exclusively on cryopreservation of immature
testicular tissue (ITT) containing spermatogonia as the only cells with reproductive potential …

Objective: Lymphatic vessels are distributed throughout the body and tightly collaborate with
blood vessels to maintain tissue homeostasis. However, the functional roles of …

Background Peripheral artery disease (PAD) is an ischemic disease with a rising incidence
worldwide. The lncRNA H19 (H19) is enriched in endothelial progenitor cells (EPCs), and …