Iron is indispensable for normal body functions across species because of its critical roles in
red blood cell function and many essential proteins and enzymes required for numerous …

Iron is an essential component in many biological processes in the human body. It is critical
for the visual phototransduction cascade in the retina. However, excess iron can be toxic …

Glaucoma can result in retinal ganglion cell (RGC) death and permanently damaged vision.
Pathologically high intraocular pressure (ph-IOP) is the leading cause of damaged vision …

Multiple sclerosis (MS) is a chronic inflammatory disease, which leads to focal demyelination
in the brain and spinal cord. Studies showed that iron released during the course of myelin …

Age-related macular degeneration (AMD) is the leading cause of irreversible visual loss in
the elderly population. With aging and the accumulated effects of environmental stress …

Oxidative stress has been implicated in the pathogenesis of age-related macular
degeneration, the leading cause of blindness in older adults, with retinal pigment epithelium …

Iron has been implicated in the pathogenesis of age‐related retinal diseases, including age‐
related macular degeneration (AMD). Previous work showed that intravitreal (IVT) injection …

Deferasirox (DFS) is an oral iron chelator that is employed in retinal ailments as a
neuroprotectant against retinal injury and thus has utility in treating disorders such as …

Background Both the accumulation of reactive oxygen species (ROS) and iron overload are
significant variables that enhance the incidence of photoreceptor cell death and retinal …

Oxidative stress plays a central role in age‐related macular degeneration (AMD). Iron, a
potent generator of hydroxyl radicals through the Fenton reaction, has been implicated in …