The resurgence of research into cancer metabolism has recently broadened interests
beyond glucose and the Warburg effect to other nutrients, including glutamine. Because …

Glutamine is an abundant and versatile nutrient that participates in energy formation, redox
homeostasis, macromolecular synthesis, and signaling in cancer cells. These characteristics …

Glutamine is the most abundant circulating amino acid in blood and muscle and is critical for
many fundamental cell functions in cancer cells, including synthesis of metabolites that …

Proliferating mammalian cells use glutamine as a source of nitrogen and as a key
anaplerotic source to provide metabolites to the tricarboxylic acid cycle (TCA) for …

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic
mutations and loss of tumor suppressors. Mounting evidence indicates that altered …

Flavonoids and other polyphenolic compounds have powerful antioxidant effects in vitro in
many test systems, but can act as pro-oxidants in some others. Whether pro-oxidant …

Mitochondria, known for more than a century as the energy powerhouse of a cell, represent
key intracellular signaling hub that are emerging as important determinants of several …

DNA damage elicits a cellular signaling response that initiates cell cycle arrest and DNA
repair. Here, we find that DNA damage triggers a critical block in glutamine metabolism …

How mitochondrial glutaminolysis contributes to redox homeostasis in cancer cells remains
unclear. Here we report that the mitochondrial enzyme glutamate dehydrogenase 1 (GDH1) …

Oncogenes influence nutrient metabolism and nutrient dependence. The oncogene c-Myc
stimulates glutamine metabolism and renders cells dependent on glutamine to sustain …