[HTML][HTML] Mesenchymal stromal cells: putative microenvironmental modulators become cell therapy
M Krampera, K Le Blanc - Cell stem cell, 2021 - cell.com
An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …
Concise review: MSC-derived exosomes for cell-free therapy
DG Phinney, MF Pittenger - Stem cells, 2017 - academic.oup.com
Mesenchymal stem cell transplantation is undergoing extensive evaluation as a cellular
therapy in human clinical trials. Because MSCs are easily isolated and amenable to culture …
therapy in human clinical trials. Because MSCs are easily isolated and amenable to culture …
Mesenchymal stem cell-derived extracellular vesicles: challenges in clinical applications
Stem cell therapy has garnered much attention and application in the past decades for the
treatment of diseases and injuries. Mesenchymal stem cells (MSCs) are studied most …
treatment of diseases and injuries. Mesenchymal stem cells (MSCs) are studied most …
Mesenchymal stromal cell exosomes ameliorate experimental bronchopulmonary dysplasia and restore lung function through macrophage immunomodulation
GR Willis, A Fernandez-Gonzalez… - American journal of …, 2018 - atsjournals.org
Rationale: Mesenchymal stem/stromal cell (MSC) therapies have shown promise in
preclinical models of pathologies relevant to newborn medicine, such as bronchopulmonary …
preclinical models of pathologies relevant to newborn medicine, such as bronchopulmonary …
Exosomes from mesenchymal stem/stromal cells: a new therapeutic paradigm
K Yin, S Wang, RC Zhao - Biomarker research, 2019 - Springer
Mesenchymal stem/stromal cells (MSCs) have been demonstrated to hold great potential for
the treatment of several diseases. Their therapeutic effects are largely mediated by …
the treatment of several diseases. Their therapeutic effects are largely mediated by …
[HTML][HTML] Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis
Objectives: Mesenchymal stem cells (MSCs) release extracellular vesicles (EVs) that display
a therapeutic effect in inflammatory disease models. Although MSCs can prevent arthritis …
a therapeutic effect in inflammatory disease models. Although MSCs can prevent arthritis …
Engineering mesenchymal stem cells to improve their exosome efficacy and yield for cell-free therapy
Through traditional medicine, there were diseases and disorders that previously remained
untreated or were simply thought to be incurable. Since the discovery of mesenchymal stem …
untreated or were simply thought to be incurable. Since the discovery of mesenchymal stem …
Small extracellular vesicles from human adipose-derived stem cells attenuate cartilage degeneration
Osteoarthritis (OA) is a chronic degenerative disease of articular cartilage that is the most
common joint disease worldwide. Mesenchymal stem cells (MSCs) have been the most …
common joint disease worldwide. Mesenchymal stem cells (MSCs) have been the most …
Exosome and mesenchymal stem cell cross-talk in the tumor microenvironment
TL Whiteside - Seminars in immunology, 2018 - Elsevier
Mesenchymal stem cells (MSCs) are a major component of the tumor microenvironment
(TME) and play a key role in promoting tumor progression. The tumor uses exosomes to co …
(TME) and play a key role in promoting tumor progression. The tumor uses exosomes to co …
Interactions between mesenchymal stem cells and the immune system
N Li, J Hua - Cellular and Molecular Life Sciences, 2017 - Springer
In addition to being multi-potent, mesenchymal stem cells (MSCs) possess
immunomodulatory functions that have been investigated as potential treatments in various …
immunomodulatory functions that have been investigated as potential treatments in various …