Antimicrobial peptides: an alternative for innovative medicines?

JP Da Costa, M Cova, R Ferreira, R Vitorino - Applied microbiology and …, 2015 - Springer
Antimicrobial peptides are small molecules with activity against bacteria, yeasts, fungi,
viruses, bacteria, and even tumor cells that make these molecules attractive as therapeutic …

Liver fluke vaccines in ruminants: strategies, progress and future opportunities

H Toet, DM Piedrafita, TW Spithill - International journal for parasitology, 2014 - Elsevier
The development of a vaccine for Fasciola spp. in livestock is a challenge and would be
advanced by harnessing our knowledge of acquired immune mechanisms expressed by …

Schistosoma mansoni Tegument Protein Sm29 Is Able to Induce a Th1-Type of Immune Response and Protection against Parasite Infection

FC Cardoso, GC Macedo, E Gava… - PLoS neglected …, 2008 - journals.plos.org
Background Schistosomiasis continues to be a significant public health problem. This
disease affects 200 million people worldwide and almost 800 million people are at risk of …

The secreted and surface proteomes of the adult stage of the carcinogenic human liver fluke Opisthorchis viverrini

J Mulvenna, B Sripa, PJ Brindley, J Gorman… - …, 2010 - Wiley Online Library
Infection with the human liver fluke, Opisthorchis viverrini, is a serious public health problem
in Thailand, Laos and nearby locations in Southeast Asia. Both experimental and …

Enzymatic shaving of the tegument surface of live schistosomes for proteomic analysis: a rational approach to select vaccine candidates

W Castro-Borges, A Dowle, RS Curwen… - PLoS neglected …, 2011 - journals.plos.org
Background The membrane-associated and membrane-spanning constituents of the
Schistosoma mansoni tegument surface, the parasite's principal interface with the host …

Development of a conserved chimeric vaccine based on helper T-cell and CTL epitopes for induction of strong immune response against Schistosoma mansoni using …

A Rahmani, M Baee, M Rostamtabar, A Karkhah… - International journal of …, 2019 - Elsevier
Currently, three recombinant antigens based vaccines are under clinical trials against
Schistosomiasis, but there is no vaccine available for prophylaxis or therapeutic. This study …

A comprehensive and critical overview of schistosomiasis vaccine candidates

A Al-Naseri, S Al-Absi, R El Ridi, N Mahana - Journal of Parasitic Diseases, 2021 - Springer
A digenetic platyhelminth Schistosoma is the causative agent of schistosomiasis, one of the
neglected tropical diseases that affect humans and animals in numerous countries in the …

Eliminating schistosomes through vaccination: what are the best immune weapons?

CT Fonseca, SC Oliveira, CC Alves - Frontiers in Immunology, 2015 - frontiersin.org
The successful development of vaccines depends on the knowledge of the immunological
mechanisms associated with the elimination of the pathogen. In the case of schistosomes, its …

Schistosoma tegument proteins in vaccine and diagnosis development: an update

CT Fonseca… - Journal of …, 2012 - Wiley Online Library
The development of a vaccine against schistosomiasis and also the availability of a more
sensitive diagnosis test are important tools to help chemotherapy in controlling disease …

Parasite annexins–new molecules with potential for drug and vaccine development

A Hofmann, A Osman, CY Leow, P Driguez… - …, 2010 - Wiley Online Library
In the last few years, annexins have been discovered in several nematodes and other
parasites, and distinct differences between the parasite annexins and those of the hosts …