Encapsulation and compartmentalization are fundamental to the evolution of cellular life, but
they also pose a challenge: how to partition the molecules that perform biological functions …

The evolutionarily conserved Sec machinery is responsible for transporting proteins across
the cytoplasmic membrane. Protein substrates of the Sec machinery must be in an unfolded …

The main bacterial pathway for inserting proteins into the plasma membrane relies on the
signal recognition particle (SRP), composed of the Ffh protein and an associated RNA …

Cotranslational protein folding studies using Force Profile Analysis, a method where the
SecM translational arrest peptide is used to detect folding‐induced forces acting on the …

The plastid stroma-localized chaperone HSP90C plays a crucial role in maintaining optimal
proteostasis within chloroplasts and participates in protein translocation processes. While …

The ATPase SecA is an essential component of the bacterial Sec machinery, which
transports proteins across the cytoplasmic membrane. Most SecA proteins contain a long C …

Most bacterial secretory proteins destined to the extracytoplasmic space are secreted
posttranslationally by the Sec translocase. SecA, a key component of the Sec system, is the …

SecA protein is a major component of the general bacterial secretory system. It is an ATPase
that couples nucleotide hydrolysis to protein translocation. In some Gram-positive …

The Sec machinery translocates proteins across, or inserts proteins into, the cytoplasmic
membrane and is responsible for translocation of approximately 20% of all proteins …

Proteins that are translocated across the cytoplasmic membrane by Sec machinery must be
in an unfolded conformation in order to pass through the protein-conducting channel during …