Catestatin is a multifunctional peptide that is involved in the regulation of the cardiovascular
and immune systems as well as metabolic homeostatis. It mitigates detrimental, excessive …

Chromogranin A (CgA)—the index member of the chromogranin/secretogranin secretory
protein family—is ubiquitously distributed in endocrine, neuroendocrine, and immune cells …

In adipose tissue, muscle, liver and macrophages, signaling by the nuclear receptor
peroxisome proliferator–activated receptor-γ (PPAR-γ) is a determinant of insulin sensitivity …

Accounting for almost one-third of the global mortality, cardiovascular diseases (CVDs)
represent a major global health issue. Emerging data suggest that most of the well …

In 1997, we identified a novel peptide, catestatin (CST: bovine chromogranin A [CHGA] 344–
364: RSMRLSFRARGYGFRGPGLQL; human CHGA352–372 …

Background: Cardiovascular disease (CVD), the most common cause of death globally,
accounts for~ 30% of all deaths worldwide. Hypertension is a common contributor to …

Chromogranin A (CgA) is a member of the granins, a family of acidic proteins found in
abundance in (neuro) endocrine cells (eg, in chromaffin cells) and in some tumors. Like …

It is increasingly clear that inflammatory diseases and cancers are influenced by cleavage
products of the pro-hormone chromogranin A (CgA), such as the 21-amino acids long …

Obesity, lipodystrophy, diabetes, and hypertension collectively constitute the main features
of Metabolic Syndrome (MetS), together with insulin resistance (IR), which is considered as …

Chromogranin A knock-out (Chga-KO) mice display increased adiposity despite high levels
of circulating catecholamines and leptin. Consistent with diet-induced obese mice …