Small-molecule fluorescent probes are attractive and versatile materials for studying
biological systems.(1-6) They can be easily loaded into cells and rapidly detect biological …

A glowing new era in cancer surgery may be dawning. Using fluorescently labelled markers,
surgical molecular navigation means that tumours and nerves can be displayed in real time …

Novel molecular imaging techniques have the potential to significantly enhance the
diagnostic and therapeutic approaches for cancer treatment. For solid tumors in particular …

We derive a physically realistic model for the generation of virtual transillumination, white
light microscopy images using epi-fluorescence measurements from thick, unsectioned …

We characterize long (up to 285 mm) gradient index (GRIN) lens endoscope systems for
multiphoton imaging. We fabricate a portable, rigid endoscope system suitable for imaging …

A method of rapidly differentiating lung tumor from healthy tissue is extraordinarily needed
for both the diagnosis and the intraoperative margin assessment. We assessed the ability of …

We use a compact and flexible multiphoton microendoscope (MPME) to acquire in vivo
images of unstained liver, kidney, and colon from an anesthetized rat. The device delivers …

Pulmonary fibrosis, characterized by excessive collagen deposition in the lungs, comprises
a key and debilitating component of chronic lung diseases. Methods are lacking for the …

During lung cancer operations a rapid and reliable assessment of tumor tissue can reduce
operation time and potentially improve patient outcomes. We show that third harmonic …

Nonlinear optical imaging (NLOI) has emerged to be a promising tool for bio-medical
imaging in recent times. Among the various applications of NLOI, its utility is the most …