Multivalent proteins and nucleic acids, collectively referred to as multivalent associative
biomacromolecules, provide the driving forces for the formation and compositional …

It is now generally accepted that macromolecules do not act in isolation but “live” in a
crowded environment, that is, an environment populated by numerous different molecules …

Eukaryotic chromatin is highly condensed but dynamically accessible to regulation and
organized into subdomains. We demonstrate that reconstituted chromatin undergoes …

Biomolecular condensates play a key role in organizing cellular fluids such as the cytoplasm
and nucleoplasm. Most of these non-membranous organelles show liquid-like properties …

Eukaryotic chromosomes contain compartments of various functions, which are marked by
and enriched with specific histone modifications. However, the molecular mechanisms by …

Biomolecular condensates, formed through phase separation, are upending our
understanding in much of molecular, cell, and developmental biology. There is an urgent …

Liquid-liquid phase separation (LLPS) has received significant attention in recent biological
studies. It refers to a phenomenon that biomolecule exceeds the solubility, condensates and …

Progress in development of biophysical analytic approaches has recently crossed paths with
macromolecule condensates in cells. These cell condensates, typically termed liquid-like …

DNA is a highly charged polyelectrolyte and is prone to associative phase separation driven
by the presence of multivalent cations, charged surfactants, proteins, polymers and colloids …

The conformational dynamics of nucleosome arrays generate a diverse spectrum of
microscopic states, posing challenges to their structural determination. Leveraging …