Five years of GWAS discovery
The past five years have seen many scientific and biological discoveries made through the
experimental design of genome-wide association studies (GWASs). These studies were …
experimental design of genome-wide association studies (GWASs). These studies were …
Axial spondyloarthritis
J Sieper, D Poddubnyy - The Lancet, 2017 - thelancet.com
The term axial spondyloarthritis covers both patients with non-radiographic and radiographic
axial spondyloarthritis, which is also termed ankylosing spondylitis. The disease usually …
axial spondyloarthritis, which is also termed ankylosing spondylitis. The disease usually …
Role of the IL-23/IL-17 pathway in rheumatic diseases: an overview
C Schinocca, C Rizzo, S Fasano, G Grasso… - Frontiers in …, 2021 - frontiersin.org
Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19)
and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced …
and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced …
Ankylosing spondylitis: etiology, pathogenesis, and treatments
Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic
inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic …
inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic …
Ankylosing spondylitis
J Braun, J Sieper - The Lancet, 2007 - thelancet.com
Ankylosing spondylitis is a common inflammatory rheumatic disease that affects the axial
skeleton, causing characteristic inflammatory back pain, which can lead to structural and …
skeleton, causing characteristic inflammatory back pain, which can lead to structural and …
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
Australo-Anglo-American Spondyloarthritis … - Nature …, 2011 - nature.com
Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the
spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent …
spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent …
Identification of multiple risk variants for ankylosing spondylitis through high-density genoty** of immune-related loci
Groupe Française d'Etude Génétique des … - Nature …, 2013 - nature.com
Ankylosing spondylitis is a common, highly heritable inflammatory arthritis affecting primarily
the spine and pelvis. In addition to HLA-B* 27 alleles, 12 loci have previously been identified …
the spine and pelvis. In addition to HLA-B* 27 alleles, 12 loci have previously been identified …
Ankylosing spondylitis: an overview
J Sieper, J Braun, M Rudwaleit, A Boonen… - Annals of the rheumatic …, 2002 - ard.bmj.com
Ankylosing spondylitis (AS) is a complex, potentially debilitating disease that is insidious in
onset, progressing to radiological sacroiliitis over several years. Patients with symptomatic …
onset, progressing to radiological sacroiliitis over several years. Patients with symptomatic …
Brief report: intestinal dysbiosis in ankylosing spondylitis
ME Costello, F Ciccia, D Willner… - Arthritis & …, 2015 - Wiley Online Library
Objective Ankylosing spondylitis (AS) is a common, highly heritable immune‐mediated
arthropathy that occurs in genetically susceptible individuals exposed to an unknown but …
arthropathy that occurs in genetically susceptible individuals exposed to an unknown but …
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci
Nature genetics, 2010 - nature.com
To identify susceptibility loci for ankylosing spondylitis, we undertook a genome-wide
association study in 2,053 unrelated ankylosing spondylitis cases among people of …
association study in 2,053 unrelated ankylosing spondylitis cases among people of …