Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …

Osteoarthritis (OA) is endemic throughout the world. An estimated 30.8 million adults in the
United States and 300 million individuals worldwide are living with OA. 1, 2 It is the leading …

Osteoarthritis (OA) is one of the most debilitating diseases and is associated with a high
personal and socioeconomic burden. So far, there is no therapy available that effectively …

Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis …

Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a
class of molecules collectively called adipokines. Initially discovered in 1994, its crucial role …

Objective Studies of previous cohorts have demonstrated an association between a status of
overweight/obesity and the presence of knee and hand osteoarthritis (OA). However, no …

Osteoarthritis (OA) is the most common joint disorder, is associated with an increasing
socioeconomic impact owing to the ageing population and mainly affects the diarthrodial …

The prevalence of osteoarthritis (OA) is rising for reasons that are not fully understood. In this
Opinion article, we review the possibility that OA is an evolutionary mismatch disease, which …

Osteoarthritis (OA) has long been considered a “wear and tear” disease leading to loss of
cartilage. OA used to be considered the sole consequence of any process leading to …

This paper provides an up-to-date review of obesity and lower limb osteoarthritis (OA). OA is
a major global cause of disability, with the knee being the most frequently affected joint …