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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin …
Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake
inhibitors (SSRIs; ie, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and …
inhibitors (SSRIs; ie, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and …
Serotonin and brain function: a tale of two receptors
Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …
achieve consensus. In this present synthesis, we integrate previous perspectives with new …
Psilocybin with psychological support for treatment-resistant depression: six-month follow-up
Rationale Recent clinical trials are reporting marked improvements in mental health
outcomes with psychedelic drug-assisted psychotherapy. Objectives Here, we report on …
outcomes with psychedelic drug-assisted psychotherapy. Objectives Here, we report on …
Insulin modulates emotional behavior through a serotonin-dependent mechanism
H Martin, S Bullich, M Martinat, M Chataigner… - Molecular …, 2024 - nature.com
Abstract Type-2 Diabetes (T2D) is characterized by insulin resistance and accompanied by
psychiatric comorbidities including major depressive disorders (MDD). Patients with T2D are …
psychiatric comorbidities including major depressive disorders (MDD). Patients with T2D are …
Genetic variants in major depressive disorder: from pathophysiology to therapy
In spite of promising preclinical results there is a decreasing number of new registered
medications in major depression. The main reason behind this fact is the lack of confirmation …
medications in major depression. The main reason behind this fact is the lack of confirmation …
Pharmacogenomics‐driven prediction of antidepressant treatment outcomes: a machine‐learning approach with multi‐trial replication
We set out to determine whether machine learning–based algorithms that included
functionally validated pharmacogenomic biomarkers joined with clinical measures could …
functionally validated pharmacogenomic biomarkers joined with clinical measures could …
PET imaging of animal models with depressive-like phenotypes
DA Vazquez-Matias, EFJ de Vries… - European journal of …, 2023 - Springer
Major depressive disorder is a growing and poorly understood pathology. Due to technical
and ethical limitations, a significant proportion of the research on depressive disorders …
and ethical limitations, a significant proportion of the research on depressive disorders …
5-HT2A Receptor Knockout Mice Show Sex-Dependent Differences following Acute Noribogaine Administration
S Villalba, B González, S Junge, A Bernardi… - International Journal of …, 2024 - mdpi.com
Noribogaine (noribo) is the primary metabolite from ibogaine, an atypical psychedelic
alkaloid isolated from the root bark of the African shrub Tabernanthe iboga. The main …
alkaloid isolated from the root bark of the African shrub Tabernanthe iboga. The main …
Translational identification of transcriptional signatures of major depression and antidepressant response
M Hervé, A Bergon, AM Le Guisquet… - Frontiers in molecular …, 2017 - frontiersin.org
Major depressive disorder (MDD) is a highly prevalent mental illness whose therapy
management remains uncertain, with more than 20% of patients who do not achieve …
management remains uncertain, with more than 20% of patients who do not achieve …
Les bases de pharmacologie fondamentale du système sérotoninergique: application à la réponse antidépressive
Résumé Si la sérotonine ou 5-hydroxytryptamine (5-HT) est peut-être plus connue pour son
rôle dans la régulation de l'humeur, il ne faut pas oublier qu'elle participe à la régulation de …
rôle dans la régulation de l'humeur, il ne faut pas oublier qu'elle participe à la régulation de …